6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine hydrochloride

Base Information

• Chemical Name: 6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine hydrochloride
• CAS No.: 1449702-79-7
• Molecular Formula: C₁₆H₁₆N₂S*ClH
• Molecular Weight: 304.843
• Mol file: 1449702-79-7.mol

Synonyms:

Chemical Property of 6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine hydrochloride

There total 4 articles about 6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C21H24N2O2S → 6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine hydrochloride (1449702-79-7)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃; for 0.166667h;

DOI:10.1039/c6md00128a

Reference yield:

2,3-dimethyl-5-phenylthiophene (40808-42-2) → 6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine hydrochloride (1449702-79-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / 0.2 h / 120 °C / Microwave irradiation

2: sodium carbonate / water; ethyl acetate / 20 °C

3: hydrogenchloride / diethyl ether / 0.17 h / 0 °C

With hydrogenchloride; sodium carbonate; In diethyl ether; water; ethyl acetate; trifluoroacetic acid;

DOI:10.1039/c6md00128a

Reference yield:

6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine → 6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine hydrochloride (1449702-79-7)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium carbonate / water; ethyl acetate / 20 °C

2: hydrogenchloride / diethyl ether / 0.17 h / 0 °C

With hydrogenchloride; sodium carbonate; In diethyl ether; water; ethyl acetate;

DOI:10.1039/c6md00128a

upstream raw materials:

2,3-dimethyl-5-phenylthiophene