40808-42-2

Upstream product

• 82671-64-5 1,2-dimethyl-1-phenylethynyloxirane 
• 121819-92-9 4-tert-Butylsulfanyl-3-methyl-1-phenyl-pent-1-yn-3-ol 
• 199451-69-9 2-(2-Methyl-thiiranyl)-4-phenyl-but-3-yn-2-ol 
• 260543-70-2 (Z)-3-methyl-1-phenylpent-2-en-4-yne-1-thiol 
• 260543-62-2 thioacetic acid (Z)-S-(3-methyl-1-phenylpent-2-en-4-ynyl) ester 
• 155268-27-2 (Z)-3-methyl-1-phenylpent-2-en-4-yn-1-ol 
• 49827-26-1 3-tert-butylsulfanyl-butan-2-one 
• 848835-90-5 4-chloro-3-methyl-1-phenyl-pent-1-yn-3-ol 
• 61285-25-4 3-bromo-2-methyl-5-phenylthiophene 
• 74-88-4 methyl iodide 
• 1403459-91-5 4-mercapto-3-methyl-1-phenylpent-1-yn-3-ol 
• 172319-78-7 2-bromo-4,5-dimethylthiophene 
• 98-80-6 phenylboronic acid 
• 632-16-6 2,3-dimethylthiophene 

Downstream Products

• 1449702-79-7 6-(4,5-dimethyl-2-phenylthiophen-3-yl)-1,6-dihydropyrimidine hydrochloride 

Relevant academic research and scientific papers

Synthesis of thiophenes in a deep eutectic solvent: heterocyclodehydration and iodocyclization of 1-mercapto-3-yn-2-ols in a choline chloride/glycerol medium

The heterocyclodehydration and iodocyclization of readily available 1-mercapto-3-yn-2-ols has been performed in a deep eutectic solvent (DES), that is, ChCl/Gly (1:2 molar ratio; ChCl=choline chloride, Gly=glycerol), as a non-conventional green solvent. T

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are thiophene compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia.

Synthesis of substituted thiophenes by palladium-catalyzed heterocyclodehydration of 1-mercapto-3-yn-2-ols in conventional and nonconventional solvents

A variety of readily available 1-mercapto-3-yn-2-ols 5 were conveniently converted into the corresponding thiophenes 6 in good to high yields in MeOH as the solvent at 50-100 °C in the presence of catalytic amounts (1-2%) of PdI2 in conjunction with KI (KI:PdI2 molar ratio = 10). The catalyst could be made recyclable employing an ionic liquid, such as BmimBF4, as the solvent under suitable conditions.

Practical synthesis of photochromic diarylethenes in integrated flow microreactor systems

An effective method for the synthesis of photochromic diarylethenes through the generation of heteroaryllithiums and subsequent reaction with octafluorocyclopentene has been developed by using integrated flow microreactor systems. Reactions can be conducted without using cryogenic conditions by virtue of effective temperature and residence time control, although much lower temperatures (-1. Therefore, the present integrated flow microreactor method serves as a practical way of synthesizing various photochromic diarylethene derivatives. Too successful to be cool: An effective method for the synthesis of photochromic diarylethenes has been developed by using integrated flow microreactor systems. Reactions can be conducted without the need for cryogenic conditions by using these systems (see picture). The synthesis of unsymmetrical diarylethenes, which is difficult to achieve by using conventional macro batch systems, has also been accomplished. Copyright

Novel synthesis of substituted thiophenes by palladium-catalyzed cycloisomerization of (Z)-2-En-4-yne-1-thiols

(formula presented) The first example of palladium-catalyzed cycloisomerization of (Z)-2-en-4-yne-1-thiols 1 to give substituted thiophenes 2 is reported. Cycloisomerization reactions are carried out under nitrogen at 25-100 °C in N,N-dimethylacetamide as

Synthesis of polysubstituted thiophenes by a catalytic cyclisation of functionalised episulfides

Substituted thiophenes are formed by the reaction of 1-alkynyl-2,3- epithioalcohols with a catalytic amount of mercury prepared from HgO and dilute sulfuric acid.