Technology Process of C14H18N2O2
There total 3 articles about C14H18N2O2 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-3-(2-propylidene)amino-4-phenylmethyl-2-oxazolidinone;
With
n-butyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 0.75h;
Inert atmosphere;
methyl iodide;
In
tetrahydrofuran; hexane;
at 0 ℃;
for 1.5h;
optical yield given as %de;
regioselective reaction;
Inert atmosphere;
DOI:10.1021/ja202267k
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium tert-butylate / tetrahydrofuran; diethyl ether / 3 h / Inert atmosphere
1.2: 1.75 h / Inert atmosphere
2.1: toluene-4-sulfonic acid / 12 h / Inert atmosphere
3.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere
3.2: 1.5 h / 0 °C / Inert atmosphere
With
n-butyllithium; potassium tert-butylate; toluene-4-sulfonic acid; diisopropylamine;
In
tetrahydrofuran; diethyl ether; hexane;
DOI:10.1021/ja202267k
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: toluene-4-sulfonic acid / 12 h / Inert atmosphere
2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 0.75 h / -78 °C / Inert atmosphere
2.2: 1.5 h / 0 °C / Inert atmosphere
With
n-butyllithium; toluene-4-sulfonic acid; diisopropylamine;
In
tetrahydrofuran; hexane;
DOI:10.1021/ja202267k
