dimethyl 7-ethyl-3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,10-hexahydropyrimido[5',4':4,5]thieno[3,2-d]azocine-8,9-dicarboxylate

Base Information

• Chemical Name: dimethyl 7-ethyl-3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,10-hexahydropyrimido[5',4':4,5]thieno[3,2-d]azocine-8,9-dicarboxylate
• CAS No.: 1415734-97-2
• Molecular Formula: C₂₄H₂₅N₃O₆S
• Molecular Weight: 483.545
• Mol file: 1415734-97-2.mol

Synonyms:

Chemical Property of dimethyl 7-ethyl-3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,10-hexahydropyrimido[5',4':4,5]thieno[3,2-d]azocine-8,9-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 7-ethyl-3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,10-hexahydropyrimido[5',4':4,5]thieno[3,2-d]azocine-8,9-dicarboxylate

There total 3 articles about dimethyl 7-ethyl-3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,10-hexahydropyrimido[5',4':4,5]thieno[3,2-d]azocine-8,9-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

7-ethyl-3-(2-methoxyphenyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one (1383841-29-9) + dimethyl acetylenedicarboxylate (762-42-5) → dimethyl 1-ethyl-3'-(2-methoxyphenyl)-6'-methylidene-4'-oxo-3',4',5,6-tetrahydro-1H-spiro[pyridine-4,5'-thieno[2,3-d]pyrimidine]-2,3-dicarboxylate (1383841-25-5) + dimethyl 7-ethyl-3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,10-hexahydropyrimido[5',4':4,5]thieno[3,2-d]azocine-8,9-dicarboxylate (1415734-97-2)

Guidance literature:

In acetonitrile; at 20 ℃; for 312h;

DOI:10.1007/s11172-012-0052-3

Reference yield:

ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate (281656-91-5) → dimethyl 1-ethyl-3'-(2-methoxyphenyl)-6'-methylidene-4'-oxo-3',4',5,6-tetrahydro-1H-spiro[pyridine-4,5'-thieno[2,3-d]pyrimidine]-2,3-dicarboxylate (1383841-25-5) + dimethyl 7-ethyl-3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,10-hexahydropyrimido[5',4':4,5]thieno[3,2-d]azocine-8,9-dicarboxylate (1415734-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / Reflux

1.2: Reflux

2.1: acetonitrile / 312 h / 20 °C

In toluene; acetonitrile; 2.1: |Stevens Rearrangement;

DOI:10.1007/s11172-012-0052-3

Reference yield:

2-methoxy-phenylamine (90-04-0) → dimethyl 1-ethyl-3'-(2-methoxyphenyl)-6'-methylidene-4'-oxo-3',4',5,6-tetrahydro-1H-spiro[pyridine-4,5'-thieno[2,3-d]pyrimidine]-2,3-dicarboxylate (1383841-25-5) + dimethyl 7-ethyl-3-(2-methoxyphenyl)-4-oxo-3,4,5,6,7,10-hexahydropyrimido[5',4':4,5]thieno[3,2-d]azocine-8,9-dicarboxylate (1415734-97-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene / Reflux

1.2: Reflux

2.1: acetonitrile / 312 h / 20 °C

In toluene; acetonitrile; 2.1: |Stevens Rearrangement;

DOI:10.1007/s11172-012-0052-3

upstream raw materials:

ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate

2-methoxy-phenylamine

7-ethyl-3-(2-methoxyphenyl)-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidin-4(3H)-one

dimethyl acetylenedicarboxylate