C₅₁H₅₇N₇O₁₃S

Base Information

• Chemical Name: C₅₁H₅₇N₇O₁₃S
• CAS No.: 1426958-03-3
• Molecular Formula: C₅₁H₅₇N₇O₁₃S
• Molecular Weight: 1008.12
• Mol file: 1426958-03-3.mol

Synonyms:

Chemical Property of C₅₁H₅₇N₇O₁₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₁H₅₇N₇O₁₃S

There total 5 articles about C₅₁H₅₇N₇O₁₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C45H53N7O14 (1417985-79-5) → C51H57N7O13S (1426958-03-3)

Guidance literature:

With 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; thiophenol; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1002/anie.201204458

Reference yield:

methyl (2R,3R)-2-azido-3-(4-(benzyloxy)phenyl)-3-hydroxypropanoate (1417985-90-0) → C51H57N7O13S (1426958-03-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: boron tribromide / water; dichloromethane / 1.33 h / -78 °C

2.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 0 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

3.2: 2-chlorotrityl chloride resin / 3 h / 20 °C / Inert atmosphere

4.1: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; thiophenol / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 4-methyl-morpholine; lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; boron tribromide; thiophenol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/anie.201204458

Reference yield:

C10H11N3O4 → C51H57N7O13S (1426958-03-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium hydroxide monohydrate / tetrahydrofuran; water / 4 h / 0 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 4 h / 20 °C / Inert atmosphere

2.2: 2-chlorotrityl chloride resin / 3 h / 20 °C / Inert atmosphere

3.1: 4-methyl-morpholine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; thiophenol / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With 4-methyl-morpholine; lithium hydroxide monohydrate; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; thiophenol; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1002/anie.201204458

upstream raw materials:

methyl (2R,3R)-2-azido-3-(4-(benzyloxy)phenyl)-3-hydroxypropanoate

N₃-(R,R)Bht-OH

N-Alloc-(S,R)Bht-OH

C₄₅H₅₃N₇O₁₄

Downstream raw materials:

C₆₆H₈₇N₁₄O₂₉P₃S