1417985-90-0

Upstream product

• 3943-97-3 methyl 4-hydroxycinnamate 
• 84184-51-0 (E)-methyl 3-(4-(benzyloxy)phenyl)acrylate 
• 100-39-0 benzyl bromide 
• 1607826-46-9 methyl (2S,3R)-3-(4-(benzyloxy)phenyl)-3-hydroxy-2-(((2-nitrophenyl)sulfonyl)oxy)propanoate 
• 1607826-45-8 methyl (2S,3R)-3-(4-(benzyloxy)phenyl)-2,3-dihydroxypropanoate 

Downstream Products

• 950839-11-9 methyl (2R,3R)-2-amino-3-(4-hydroxyphenyl)-3-methoxypropanoate 
• 1607826-48-1 methyl (2R,3R)-2-(((allyloxy)carbonyl)amino)-3-(4-hydroxyphenyl)-3-methoxypropanoate 
• 1607826-49-2 methyl (2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoate 
• 1607826-15-2 (2R,3R)-2-(((allyloxy)carbonyl)amino)-3-methoxy-3-(4-(trityloxy)phenyl)propanoic acid 
• 1607826-47-0 methyl (2R,3R)-2-azido-3-(4-(benzyloxy)phenyl)-3-methoxypropanoate 
• 1426958-03-3 C₅₁H₅₇N₇O₁₃S 
• 1417985-79-5 C₄₅H₅₃N₇O₁₄ 
• 1417985-84-2 N₃-(R,R)Bht-OH 

Relevant academic research and scientific papers

Stellatolides, a new cyclodepsipeptide family from the sponge ecionemia acervus: Isolation, solid-phase total synthesis, and full structural assignment of stellatolide a

The marine environment is a rich source of metabolites with potential therapeutic properties and applications for humans. Here we describe the first isolation, solid-phase total synthesis, and full structural assignment of a new class of cyclodepsipeptides from the Madagascan sponge Ecionemia acervus that shows in vitro cytotoxic activities at submicromolar concentrations. Seven structures belonging to a new family of compounds, given the general name stellatolides, were characterized. The sequence and stereochemistry of all the amino acids in these molecules were established by a combination of spectroscopic analysis, chemical degradation, and derivatization studies. Furthermore, the complete structure of stellatolide A was confirmed by an efficient solid-phase method for the first total synthesis and the full structural assignment of this molecule, including the asymmetric synthesis of the unique B-hydroxy acid moiety (Z)-3-hydroxy-6,8-dimethylnon-4-enoic acid.