C₁₈H₁₁Cl₃FN₅O₂

Base Information

Chemical Name:C₁₈H₁₁Cl₃FN₅O₂
CAS No.:1093257-12-5
Molecular Formula:C₁₈H₁₁Cl₃FN₅O₂
Molecular Weight:454.675
Hs Code.:

C<sub>18</sub>H<sub>11</sub>Cl<sub>3</sub>FN<sub>5</sub>O<sub>2</sub>

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₈H₁₁Cl₃FN₅O₂

Chemical Property:

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Technology Process of C₁₈H₁₁Cl₃FN₅O₂

There total 8 articles about C₁₈H₁₁Cl₃FN₅O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093268-14-4
2-azido-4-chloro-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1H-imidazole-5-carboxamide

: 1093257-12-5
C₁₈H₁₁Cl₃FN₅O₂

Guidance literature:: With hydrogen; In ethyl acetate; for 2h; under 2585.81 Torr;
DOI:10.1021/jm301294g

Reference yield:

: 1093260-71-9
bis(1,1-dimethylethyl) {3-[(3-chloro-5-cyanophenyl)oxy]-2-fluoro-4-nitrophenyl}propanedioate

: 1093257-12-5
C₁₈H₁₁Cl₃FN₅O₂

Guidance literature:: Multi-step reaction with 8 steps

1: trifluoroacetic acid / dichloromethane / 2 h / Reflux

2: copper(I) oxide / acetonitrile / 2 h / Reflux

3: sodium dithionite; water / tetrahydrofuran / 1 h

4: copper dichloride; tert.-butylnitrite / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

5: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 85 °C

6: ammonia / dichloromethane; methanol / 2 h

7: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 20 °C

8: hydrogen / ethyl acetate / 2 h / 2585.81 Torr

With copper(I) oxide; N-Bromosuccinimide; tert.-butylnitrite; sodium dithionite; 2,2'-azobis(isobutyronitrile); ammonia; water; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; copper dichloride; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm301294g

Reference yield:

: 1093260-77-5
3-[(6-amino-2-fluoro-3-methylphenyl)oxy]-5-chlorobenzonitrile

: 1093257-12-5
C₁₈H₁₁Cl₃FN₅O₂

Guidance literature:: Multi-step reaction with 5 steps

1: copper dichloride; tert.-butylnitrite / acetonitrile / 0.5 h / 50 °C / Inert atmosphere

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 85 °C

3: ammonia / dichloromethane; methanol / 2 h

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / 20 °C

5: hydrogen / ethyl acetate / 2 h / 2585.81 Torr

With N-Bromosuccinimide; tert.-butylnitrite; 2,2'-azobis(isobutyronitrile); ammonia; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; copper dichloride; In methanol; tetrachloromethane; dichloromethane; ethyl acetate; acetonitrile;
DOI:10.1021/jm301294g