(R)(+)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate

Base Information

Chemical Name:(R)(+)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate
CAS No.:79784-51-3
Molecular Formula:C₄₆H₄₇F₃N₂O₈
Molecular Weight:812.883
Hs Code.:

(R)(+)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate

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Chemical Property of (R)(+)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate

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Technology Process of (R)(+)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate

There total 12 articles about (R)(+)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 51973-93-4
N-benzyl-2-(3,4-dimethoxyphenyl)ethylamine

: 79784-51-3,79784-53-5
(S)(-)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) conc. HCl / 1.) methanol, 4.5 h, reflux, 2.) acetone, 20 min, ice bath, overnight, room temperature

2: K₂CO₃ / acetone; H₂O / 5 h / Heating

3: pyridine / CCl₄ / 24 h / Ambient temperature

With pyridine; hydrogenchloride; potassium carbonate; In tetrachloromethane; water; acetone;
DOI:10.1248/cpb.29.2157

Reference yield:

: 51973-93-4
N-benzyl-2-(3,4-dimethoxyphenyl)ethylamine

: 79784-51-3
(R)(+)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) conc. HCl / 1.) methanol, 4.5 h, reflux, 2.) acetone, 20 min, ice bath, overnight, room temperature

2: K₂CO₃ / acetone; H₂O / 5 h / Heating

3: pyridine / CCl₄ / 24 h / Ambient temperature

With pyridine; hydrogenchloride; potassium carbonate; In tetrachloromethane; water; acetone;
DOI:10.1248/cpb.29.2157

Reference yield:

: 79784-54-6
5-hydroxy-8-(2-tetrahydropyranyloxy)-3,4-dihydrocarbostyril

: 79784-51-3,79784-53-5
(S)(-)-8-benzyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril (+)-α-methoxy-α-trifluoromethylphenylacetate

Guidance literature:: Multi-step reaction with 5 steps

1: 21 percent / piperidine / dimethylformamide / 9.5 h / 60 - 65 °C

2: 83 percent / 3.5N KOH / methanol / 1 h / Ambient temperature

3: 2.) conc. HCl / 1.) methanol, 4.5 h, reflux, 2.) acetone, 20 min, ice bath, overnight, room temperature

4: K₂CO₃ / acetone; H₂O / 5 h / Heating

5: pyridine / CCl₄ / 24 h / Ambient temperature

With piperidine; pyridine; hydrogenchloride; potassium hydroxide; potassium carbonate; In methanol; tetrachloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.29.2157