51973-93-4

Upstream product

• 100-52-7 benzaldehyde 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 10133-74-1 N-phenylmethylene-2-(3,4-dimethoxyphenyl)ethylamine 
• 4230-93-7 3,4-dimethoxynitrostyrene 
• 100-51-6 benzyl alcohol 
• 98062-25-0 tert-butyl N-[2-(3,4-dimethoxyphenyl)ethyl]carbamate 
• 100-39-0 benzyl bromide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 

Downstream Products

• 37491-72-8 N-Bnezyldopamine 
• 31756-14-6 2-benzyl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline 
• 208348-21-4 2-Benzyl-6,7-dimethoxy-1-[1-phenyl-meth-(E)-ylidene]-1,2,3,4-tetrahydro-isoquinoline 
• 212578-37-5 6-(3-{Benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amino}-propyl)-2,3-dihydro-8H-1,4,5-trioxa-8-aza-anthracen-7-one 
• 62717-54-8 N-benzyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-hydroxy-2-(4-chlorophenyl)-ethylamine 
• 70111-67-0 1-(6,7-Dimethoxy-4(3H)-quinazolinone-3-yl)-3-[N-benzyl-N-(2-(3,4-dimethoxy-phenyl)-ethyl)-amino]-propane 
• 1223736-47-7 2-{benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amino}-N,N-dimethyl-acetamide 
• 1223736-33-1 benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-ethyl-amine 
• 1223736-43-3 2-{benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amino}-acetamide 
• 36764-88-2 5-{benzyl-[2-(3,4-dimethoxy-phenyl)-ethyl]-amino}-2-(3,4-dimethoxy-phenyl)-2-isopropyl-pentanenitrile 
• 65458-21-1 N-benzyl-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-hydroxy-2-(2-chlorophenyl)ethylamine 
• 74245-70-8 (S)(-)-8-acetonyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril 
• 74245-70-8 (R)(+)-8-acetonyloxy-5-<3-(N-benzyl-3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril 
• 79784-50-2 (S)(-)-8-acetonyloxy-5-<3-(3,4-dimethoxyphenethylamino)-2-hydroxypropoxy>-3,4-dihydrocarbostyril 

Relevant academic research and scientific papers

A Base and Solvent-Free Ruthenium-Catalyzed Alkylation of Amines

A (pyridyl)phosphine-ligated ruthenium(II) catalyst is reported for the chemoselective benzylic N-alkylation of amines, via a hydrogen-borrowing mechanism. The catalyst operates under mild conditions, neat, and without a base or other additive. These conditions offer remarkable functional group compatibility for applications in organic synthesis, including reactions involving phenols and anilines, which are very difficult to achieve. Mechanistic studies suggest that, unlike other catalysts for this reaction, the redox steps are fast and reversible while imine formation is slow. We perceive that this is the origin of the selectivity realized with these reaction conditions.

Synthesis of new verapamil analogues and their evaluation in combination with rifampicin against Mycobacterium tuberculosis and molecular docking studies in the binding site of efflux protein Rv1258c

New verapamil analogues were synthesized and their inhibitory activities against Mycobacterium tuberculosis H37Rv determined in vitro alone and in combination with rifampicin (RIF). Some analogues showed comparable activity to verapamil and exhibited better synergies with RIF. Molecular docking studies of the binding sites of Rv1258c, a M. tuberculosis efflux protein previously implicated in intrinsic resistance to RIF, suggested a potential rationale for the superior synergistic interactions observed with some analogues.

NOVEL METHOD OF PREPARING SECONDARY AMINE COMPOUND USING MICROFLOW REACTOR

Disclosed is a novel method of preparing a secondary amine compound using a microflow reactor. According to the method, a primary amine compound and a halide compound are allowed to react with each other in the microflow reactor, such that the production

NOVEL METHOD OF PREPARING SECONDARY AMINE COMPOUND USING MICROFLOW REACTOR

Disclosed is a novel method of preparing a secondary amine compound using a microflow reactor. According to the method, a primary amine compound and a halide compound are allowed to react with each other in the microflow reactor, such that the production

PHENETHYLAMIDE DERIVATIVES AND THEIR HETEROCYCLIC ANALOGUES

The invention relates to novel phenethylamide derivatives and their heterocyclic analogues of formula (I), wherein A, B, R1, R2 and R3 are as described in the application, and to the use of such compounds, or of pharmaceut

SYNTHESES BASED ON &β-PHENYLETHYLAMINES V. SYNTHESIS AND PRELIMINARY PHARMACOLOGICAL SCREENING OF SOME PHENYLALKYLAMINES AND N-BENZYLTETRAHYDROISOQUINOLINES

The synthetic series of substituted N-benzyltetrahydroisoquinolines has been continued and the pharmacological activities of the compounds obtained have been investigated.

A Convenient Synthesis of Apogalanthamine Analogues as α-Adrenergic Blocking Agents using Zerovalent Nickel

The apogalanthamine analogues, 5,6,7,8-tetrahydrodibenzazocine (2) and its N-methyl and N-acetyl derivatives (1 and 3), and the methoxy derivatives (4, 5 and 9) of (1) were obtained in good yields by cyclization of the corresponding halogeno-N-benzyl-β-phenethylamines (10a, 11a-d, 12a,b and 13a-c) using stoichiometric amounts of zerovalent nickel generated in situ and potassium iodide.

A Facile Sythesis of 1,2,3,4-Tetrahydroisoquinolines Through Cyclization of O,N-Acetals

A mild and efficient method for the synthesis of 1,2,3,4-tetrahydroisoquinolines by a modified Pictet-Spengler reaction involving Lewis acid-mediated cyclization of O,N-acetals is described.

Synthesis, Positive and Negative Ion Mass Spectra and Microbial Activity of N-Benzyltetrahydroisoquinolines

Substituted N-benzyltetrahydroisoquinolines (5-11) have been synthesised and their positive and negative ion mass spectra studied.The M+. of these compounds are fairly stable and abundant RDA fragment ions (often corresponding to the base peaks) are observed in their positive ion EI spectra.However, under negative ion conditions these molecules fragment in a similar way as that of 1-benzyltetrahydroisoquinolines.The base (5-11) hydrochlorides when tested against a number of fungi and bacteria do not exhibit any promising activity.