C₂₁H₂₇N₅O*ClH

Base Information

• Chemical Name: C₂₁H₂₇N₅O*ClH
• CAS No.: 1338251-69-6
• Molecular Formula: C₂₁H₂₇N₅O*ClH
• Molecular Weight: 401.939
• Mol file: 1338251-69-6.mol

Synonyms:

Chemical Property of C₂₁H₂₇N₅O*ClH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₇N₅O*ClH

There total 14 articles about C₂₁H₂₇N₅O*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyanopiperidine (4395-98-6) → C21H27N5O*ClH (1338251-69-6)

Guidance literature:

Multi-step reaction with 10 steps

1: triethylamine / dichloromethane / 0 - 20 °C

2: lithium diisopropyl amide / tetrahydrofuran / -78 - 20 °C

3: platinum(IV) oxide; hydrogen / acetic acid / 20 °C

4: sodium hydrogencarbonate / dichloromethane / 0 - 20 °C

5: water; sodium hydroxide / ethanol / Reflux

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

7: pyridine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

8: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

9: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

10: hydrogenchloride / ethyl acetate

With pyridine; hydrogenchloride; platinum(IV) oxide; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ethanol; dichloromethane; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.07.087

Reference yield:

C12H21N3O2 (1207178-51-5) → C21H27N5O*ClH (1338251-69-6)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / ethyl acetate

With hydrogenchloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.07.087

Reference yield:

1-tert-butyl 4-ethyl 4-(aminomethyl)piperidine-1,4-dicarboxylate (1016258-69-7) → C21H27N5O*ClH (1338251-69-6)

Guidance literature:

Multi-step reaction with 7 steps

1: sodium hydrogencarbonate / dichloromethane / 0 - 20 °C

2: water; sodium hydroxide / ethanol / Reflux

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

4: pyridine; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

6: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 20 °C

7: hydrogenchloride / ethyl acetate

With pyridine; hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic anhydride; sodium hydroxide; In methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1016/j.bmcl.2011.07.087

upstream raw materials:

4-cyanopiperidine

C₁₂H₂₁N₃O₂

1-tert-butyl 4-ethyl 4-(aminomethyl)piperidine-1,4-dicarboxylate

4-benzyloxycarbonylaminomethyl-4-ethoxycarbonylpiperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

C₂₉H₃₅N₅O

C₂₉H₃₂F₃N₅O

C₂₉H₃₅N₅O₂

C₂₉H₃₂F₃N₅O