N-(4-butylphenyl)-4-fluorobenzenesulfonamide

Base Information

• Chemical Name: N-(4-butylphenyl)-4-fluorobenzenesulfonamide
• CAS No.: 346692-04-4
• Molecular Formula: C₁₆H₁₈FNO₂S
• Molecular Weight: 307.389
• European Community (EC) Number: 809-022-2
• ChEMBL ID: CHEMBL3931570
• Mol file: 346692-04-4.mol

Synonyms:DC260126;346692-04-4;N-(4-butylphenyl)-4-fluorobenzenesulfonamide;DC-260126;CHEMBL3931570;DC 260126;Oprea1_825888;SCHEMBL18058899;BCP32685;WNA69204;BDBM50196405;MFCD00784423;STK076838;AKOS003265834;CS-7709;NCGC00387268-04;AS-16530;HY-101906;C74786;N-(4-butylphenyl)-4-fluoro-1-benzenesulfonamide;N-(4-Butylphenyl)-4-fluorobenzene-1-sulfonamide;A899626

Chemical Property of N-(4-butylphenyl)-4-fluorobenzenesulfonamide

Chemical Property:

• Storage Temp.: ?20°C
• Solubility.: DMSO: soluble20mg/mL, clear
• XLogP3: 4.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 307.10422815
• Heavy Atom Count: 21
• Complexity: 391

Purity/Quality:

99%+, ^*data from raw suppliers

DC 260126 ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26

MSDS Files:

Useful:

• Canonical SMILES: CCCCC1=CC=C(C=C1)NS(=O)(=O)C2=CC=C(C=C2)F
• Description: DC260126 is a free fatty acid receptor 1 (FFAR1/GPR40) antagonist that inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic, oleic, palmitoleic, and lauric acid (Item Nos. 90150, 90260, 10009871, and 10006626, respectively) with IC50 values of 6.28, 5.96, 7.07, and 4.58 μM, respectively. At 10 mg/kg, it has been shown to inhibit glucose-stimulated insulin secretion, to reduce blood insulin levels, to improve insulin sensitivity, and to decrease the rate of pancreatic β-cell apoptosis in obese diabetic db/db mice.

Technology Process of N-(4-butylphenyl)-4-fluorobenzenesulfonamide

There total 1 articles about N-(4-butylphenyl)-4-fluorobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-Butylaniline (104-13-2) + 4-Fluorobenzenesulfonyl chloride (349-88-2) → DC260126 (346692-04-4)

Guidance literature:

In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.6b00685

upstream raw materials:

4-Butylaniline

4-Fluorobenzenesulfonyl chloride

Refernces