ethyl 4-benzoyl-4H-furo[3,2-b]pyrrole-5-carboxylate

Base Information

• Chemical Name: ethyl 4-benzoyl-4H-furo[3,2-b]pyrrole-5-carboxylate
• CAS No.: 1501968-64-4
• Molecular Formula: C₁₆H₁₃NO₄
• Molecular Weight: 283.284
• Mol file: 1501968-64-4.mol

Synonyms:

Chemical Property of ethyl 4-benzoyl-4H-furo[3,2-b]pyrrole-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 4-benzoyl-4H-furo[3,2-b]pyrrole-5-carboxylate

There total 6 articles about ethyl 4-benzoyl-4H-furo[3,2-b]pyrrole-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(E)-ethyl 2-benzamido-3-(3-bromofuran-2-yl)acrylate → 4H-Furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester (35405-94-8) + ethyl 4-benzoyl-4H-furo[3,2-b]pyrrole-5-carboxylate (1501968-64-4)

Guidance literature:

(E)-ethyl 2-benzamido-3-(3-bromofuran-2-yl)acrylate; With copper(l) iodide; caesium carbonate; In toluene; at 90 ℃; for 2h;

With (E)-ethyl 2-benzamido-3-(3-bromofuran-2-yl)acrylate; In toluene; at 110 ℃; for 2h; Reagent/catalyst; Overall yield = 94 %;

DOI:10.1021/op4001737

Reference yield:

C14H8BrNO3 → ethyl 4-benzoyl-4H-furo[3,2-b]pyrrole-5-carboxylate (1501968-64-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 80 °C

2: caesium carbonate; copper(l) iodide / toluene / 7 h / Inert atmosphere; Reflux; Large scale

With copper(l) iodide; caesium carbonate; In ethanol; toluene;

DOI:10.1021/op4001737

Reference yield:

3-bromofurfural (14757-78-9) → ethyl 4-benzoyl-4H-furo[3,2-b]pyrrole-5-carboxylate (1501968-64-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate; acetic anhydride / toluene / Inert atmosphere; Reflux

2: ethanol / 80 °C

3: caesium carbonate; copper(l) iodide / toluene / 7 h / Inert atmosphere; Reflux; Large scale

With copper(l) iodide; sodium acetate; acetic anhydride; caesium carbonate; In ethanol; toluene; 1: |Erlenmeyer-Plochl-Bergmann;

DOI:10.1021/op4001737

upstream raw materials:

3-bromofurfural

Downstream raw materials:

4H-Furo[3,2-b]pyrrole-5-carboxylic acid ethyl ester