MAK-683

Base Information

Chemical Name:MAK-683
CAS No.:1951408-58-4
Molecular Formula:C₂₀H₁₇FN₆O
Molecular Weight:376.393
Hs Code.:
Mol file:1951408-58-4.mol

Synonyms:

Suppliers and Price of MAK-683

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MAK-683
1mg
$ 85.00

DC Chemicals
MAK683 >98%
250 mg
$ 1200.00

DC Chemicals
MAK683 >98%
100 mg
$ 700.00

ChemScene
MAK683 98.05%
25mg
$ 530.00

ChemScene
MAK683 98.05%
10mg
$ 240.00

ChemScene
MAK683 98.05%
100mg
$ 1150.00

ChemScene
MAK683 98.05%
50mg
$ 790.00

ChemScene
MAK683 98.05%
5mg
$ 130.00

Cayman Chemical
MAK-683
5mg
$ 276.00

Cayman Chemical
MAK-683
1mg
$ 65.00

Total 8 raw suppliers

Chemical Property of MAK-683

Chemical Property:

PKA:2.70±0.12(Predicted)
Density:1.47±0.1 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

MAK-683 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description MAK-683 is an inhibitor of trimethylation of histone 3 lysine 27 (H3K27) by polycomb repressive complex 2 (PRC2), a complex that includes embryonic ectoderm development protein (EED). MAK-683 has an IC50 value of 5.9 nM in an EED-H3K27me3 peptide competition binding assay and inhibits H3K27 trimethylation in G401 cells (IC50 = 2.6 nM). It inhibits proliferation of KARPAS422 B cell lymphoma cells with an IC50 value of 3 nM.
Uses MAK-683 is a useful intermediate for the preparation of triazolopyrimidine compounds useful in the treatment of diseases or disorders mediated by EED and/or PRC2. EED inhibitor-1.

Technology Process of MAK-683

There total 8 articles about MAK-683 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1012084-56-8
2-methyl-3-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine

: 8-bromo-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

: 1951408-58-4
N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; In 1,4-dioxane; water; at 110 ℃; for 1h; Inert atmosphere;

Reference yield: 46.0%

: 8-bromo-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

: 899436-71-6
(2-methylpyridin-3-yl)boronic acid

: 1951408-58-4
N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In water; acetonitrile; at 110 ℃; for 3h; Inert atmosphere;

Reference yield:

: 99451-55-5
8-bromo-5-(methylthio)-[1,2,4]triazolo[4,3-c]pyrimidine

: 1951408-58-4
N-((5-fluoro-2,3-dihydrobenzofuran-4-yl)methyl)-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 16 h / 40 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate / 1,4-dioxane; water / 1 h / 110 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium hydrogencarbonate; In 1,4-dioxane; water;