C₉H₅ClF₃NO₂

Base Information

• Chemical Name: C₉H₅ClF₃NO₂
• CAS No.: 1443666-03-2
• Molecular Formula: C₉H₅ClF₃NO₂
• Molecular Weight: 251.592
• Mol file: 1443666-03-2.mol

Synonyms:

Chemical Property of C₉H₅ClF₃NO₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₉H₅ClF₃NO₂

There total 1 articles about C₉H₅ClF₃NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C9H3ClF3NO (1443666-02-1) → C9H5ClF3NO2 (1443666-03-2)

Guidance literature:

With sulfuric acid; water;

DOI:10.1080/00397911.2012.696306

Reference yield:

C9H5ClF3NO2 (1443666-03-2) → (E)-3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid (877766-45-5)

Guidance literature:

Multi-step reaction with 6 steps

1: thionyl chloride

2: potassium carbonate / isopropyl alcohol / 0.5 h / 50 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; caesium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C

4: methanol; sodium tetrahydroborate / 1.25 h / 55 - 60 °C

5: manganese(IV) oxide / dichloromethane / 2 h / 35 °C

6: piperidine; pyridine / 2 h / 65 °C

With piperidine; pyridine; methanol; manganese(IV) oxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; thionyl chloride; potassium carbonate; caesium carbonate; In dichloromethane; dimethyl sulfoxide; isopropyl alcohol; 3: |Buchwald-Hartwig Coupling / 6: |Knoevenagel Condensation;

DOI:10.1080/00397911.2012.696306

Reference yield:

C9H5ClF3NO2 (1443666-03-2) → methyl 2-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(2,4-dichlorobenzyl)hydrazono)acetate (1443666-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride

2: potassium carbonate / isopropyl alcohol / 0.5 h / 50 °C

With thionyl chloride; potassium carbonate; In isopropyl alcohol;

DOI:10.1080/00397911.2012.696306

upstream raw materials:

C₉H₃ClF₃NO

Downstream raw materials:

1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazole-3-carbaldehyde

(E)-3-(1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazol-3-yl)acrylic acid

methyl 2-(2-chloro-4-(trifluoromethyl)phenyl)-2-(2-(2,4-dichlorobenzyl)hydrazono)acetate

methyl 1-(2,4-dichlorobenzyl)-6-(trifluoromethyl)-1H-indazole-3-carboxylate