Methyl3-(4-chlorophenyl)-1H-pyrazole-4-carboxylate

Base Information

• Chemical Name: Methyl3-(4-chlorophenyl)-1H-pyrazole-4-carboxylate
• CAS No.: 135641-70-2
• Molecular Formula: C₁₁H₉ClN₂O₂
• Molecular Weight: 236.658
• Mol file: 135641-70-2.mol

Synonyms:

Chemical Property of Methyl3-(4-chlorophenyl)-1H-pyrazole-4-carboxylate

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl3(5)-(4-chlorophenyl)-1H-pyrazole-4-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl3-(4-chlorophenyl)-1H-pyrazole-4-carboxylate

There total 4 articles about Methyl3-(4-chlorophenyl)-1H-pyrazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

diazomethane (186581-53-3,908094-01-9,334-88-3) + 3-p-chlorophenyl-1H-pyrazole-4-carboxylic acid (135641-91-7) → 3-p-chlorophenyl-4-methoxycarbonyl-1H-pyrazole (135641-70-2)

Guidance literature:

In diethyl ether; dichloromethane; for 0.166667h; Ambient temperature;

Reference yield: 11.0%

c-4-p-chlorobenzoyloxy-3-p-chlorophenyl-r-3-methoxycarbonyl-4,5-dihydro-3H-pyrazole (135641-68-8) → 3-(4-chlorophenyl)-1H-pyrazole (59843-58-2) + methyl 3-(4-chlorophenyl)-1H-pyrazole-1-carboxylate (135641-71-3) + 3-p-chlorophenyl-4-methoxycarbonyl-1H-pyrazole (135641-70-2) + 5-p-chlorophenyl-1-methoxycarbonyl-1H-pyrazole

Guidance literature:

With triethylamine; In dichloromethane; for 24h;

Reference yield:

dimethyl 2-(4-chlorophenyl)maleate (109842-38-8) → 3-p-chlorophenyl-4-methoxycarbonyl-1H-pyrazole (135641-70-2)

Guidance literature:

Multi-step reaction with 3 steps

1: CH₂Cl₂; diethyl ether / 24 h / Ambient temperature

2: 1.) Br₂, 2.) conc. HCl / 1.) CH₂Cl₂,, RT, 30 min, 2.) reflux, 1 d

3: 41 percent / CH₂Cl₂; diethyl ether / 0.17 h / Ambient temperature

With hydrogenchloride; bromine; In diethyl ether; dichloromethane;

upstream raw materials:

diazomethane

3-p-chlorophenyl-1H-pyrazole-4-carboxylic acid

c-4-p-chlorobenzoyloxy-3-p-chlorophenyl-r-3-methoxycarbonyl-4,5-dihydro-3H-pyrazole

dimethyl 2-(4-chlorophenyl)maleate

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