((S)-1-Methoxymethyl-2-methyl-propyl)-(2-phenyl-but-1-enylidene)-amine

Base Information

• Chemical Name: ((S)-1-Methoxymethyl-2-methyl-propyl)-(2-phenyl-but-1-enylidene)-amine
• CAS No.: 85021-36-9
• Molecular Formula: C₁₆H₂₃NO
• Molecular Weight: 245.365
• Mol file: 85021-36-9.mol

Synonyms:

Chemical Property of ((S)-1-Methoxymethyl-2-methyl-propyl)-(2-phenyl-but-1-enylidene)-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ((S)-1-Methoxymethyl-2-methyl-propyl)-(2-phenyl-but-1-enylidene)-amine

There total 7 articles about ((S)-1-Methoxymethyl-2-methyl-propyl)-(2-phenyl-but-1-enylidene)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-((S)-1-Methoxymethyl-2-methyl-propyl)-2-phenyl-butyrimidoyl chloride → ((S)-1-Methoxymethyl-2-methyl-propyl)-(2-phenyl-but-1-enylidene)-amine (85021-36-9)

Guidance literature:

With triethylamine; In benzene; for 18h; Yield given; Heating;

Reference yield:

N-((S)-1-methoxy-3-methyl-2-butyl)-2-phenylbutyramide (85021-41-6) → ((S)-1-Methoxymethyl-2-methyl-propyl)-(2-phenyl-but-1-enylidene)-amine (85021-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: PCl₅ / benzene / 3 h / Heating

2: Et₃N / benzene / Heating

With phosphorus pentachloride; triethylamine; In benzene;

DOI:10.1246/cl.1982.1871

Reference yield:

(S)-valinol (2026-48-4,473-75-6) → ((S)-1-Methoxymethyl-2-methyl-propyl)-(2-phenyl-but-1-enylidene)-amine (85021-36-9)

Guidance literature:

Multi-step reaction with 6 steps

1: benzene / Heating

2: sodium hydride / tetrahydrofuran / 1.) room temp., 1 h; 2.) 0 deg C, 16 h; 3.) room temp., 18 h

3: 10percent aq. hydrochloric acid

4: triethylamine / tetrahydrofuran / 17 h / Ambient temperature

5: phosphorus pentachloride / benzene / 3 h / Heating

6: triethylamine / benzene / 18 h / Heating

With hydrogenchloride; phosphorus pentachloride; sodium hydride; triethylamine; In tetrahydrofuran; benzene;

upstream raw materials:

N-((S)-1-methoxy-3-methyl-2-butyl)-2-phenylbutyramide

(S)-valinol

L-valine ethyl ester

(S)-2-amino-1-methoxy-3-methylbutane

Downstream raw materials:

((S)-1-Methoxymethyl-2-methyl-propyl)-[1-methyl-2-methylsulfanylmethyl-2-phenyl-but-(E)-ylidene]-amine

((S)-1-Methoxymethyl-2-methyl-propyl)-[1-methyl-2-methylsulfanylmethyl-2-phenyl-but-(E)-ylidene]-amine