1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide oxalate

Base Information

• Chemical Name: 1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide oxalate
• CAS No.: 690272-71-0
• Molecular Formula: C₂H₂O₄*C₂₄H₃₁N₃O₃
• Molecular Weight: 499.564
• Mol file: 690272-71-0.mol

Synonyms:

Chemical Property of 1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide oxalate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide oxalate

There total 6 articles about 1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide oxalate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide (690272-70-9) + oxalic acid (144-62-7,97993-78-7) → 1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide oxalate (690272-71-0)

Guidance literature:

In di-isopropyl ether;

Reference yield:

1-benzyl-4-phenylaminopiperidine-4-carboxylic acid amide (1096-03-3) → 1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide oxalate (690272-71-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium hydroxide / ethylene glycol / 20 h / Heating / reflux

1.2: 20 °C

2.1: water; propionic acid anhydride / water; propionic acid anhydride / 2 h / 70 °C / Heating / reflux

3.1: diethyl cyanophosphonate; triethylamine / DMF (N,N-dimethyl-formamide) / 16 h / 0 - 20 °C

4.1: di-isopropyl ether

With potassium hydroxide; diethyl cyanophosphonate; water; propionic acid anhydride; triethylamine; In DMF (N,N-dimethyl-formamide); di-isopropyl ether; water; ethylene glycol; propionic acid anhydride;

Reference yield:

1-phenylmethyl-4-piperidone (3612-20-2) → 1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide oxalate (690272-71-0)

Guidance literature:

Multi-step reaction with 6 steps

1.1: acetic acid / 1.17 h / 0 - 40 °C

1.2: 0 °C / pH 10

2.1: sulfuric acid / 0 - 25 °C

2.2: 0 °C

3.1: potassium hydroxide / ethylene glycol / 20 h / Heating / reflux

3.2: 20 °C

4.1: water; propionic acid anhydride / water; propionic acid anhydride / 2 h / 70 °C / Heating / reflux

5.1: diethyl cyanophosphonate; triethylamine / DMF (N,N-dimethyl-formamide) / 16 h / 0 - 20 °C

6.1: di-isopropyl ether

With potassium hydroxide; diethyl cyanophosphonate; sulfuric acid; water; propionic acid anhydride; triethylamine; In DMF (N,N-dimethyl-formamide); di-isopropyl ether; water; ethylene glycol; acetic acid; propionic acid anhydride;

upstream raw materials:

1-benzyl-N-methoxy-N-methyl-4-[phenyl(propionyl)amino]-4-piperidinecarboxamide

oxalic acid

1-phenylmethyl-4-piperidone

1-benzyl-4-(phenylamino)piperidine-4-carbonitrile

Refernces