(2R,3S,4S,4aS,8aR)-2-Benzenesulfonyloxymethyl-4-dimethylcarbamoylmethyl-3-hydroxy-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

Base Information

Chemical Name:(2R,3S,4S,4aS,8aR)-2-Benzenesulfonyloxymethyl-4-dimethylcarbamoylmethyl-3-hydroxy-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester
CAS No.:98875-19-5
Molecular Formula:C₂₅H₃₃NO₈S
Molecular Weight:507.605
Hs Code.:

(2R,3S,4S,4aS,8aR)-2-Benzenesulfonyloxymethyl-4-dimethylcarbamoylmethyl-3-hydroxy-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

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Chemical Property of (2R,3S,4S,4aS,8aR)-2-Benzenesulfonyloxymethyl-4-dimethylcarbamoylmethyl-3-hydroxy-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

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Technology Process of (2R,3S,4S,4aS,8aR)-2-Benzenesulfonyloxymethyl-4-dimethylcarbamoylmethyl-3-hydroxy-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

There total 11 articles about (2R,3S,4S,4aS,8aR)-2-Benzenesulfonyloxymethyl-4-dimethylcarbamoylmethyl-3-hydroxy-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 98-09-9
benzenesulfonyl chloride

: 98875-29-7
(2R,3S,4S,4aS,8aR)-4-Dimethylcarbamoylmethyl-3-hydroxy-2-hydroxymethyl-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

: 98875-19-5
(2R,3S,4S,4aS,8aR)-2-Benzenesulfonyloxymethyl-4-dimethylcarbamoylmethyl-3-hydroxy-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

Guidance literature:: With pyridine;
DOI:10.1021/jo00223a053

Reference yield:

: 98875-28-6
(2R,3R,4aR,8aR)-3-Hydroxy-2-hydroxymethyl-7-methyl-4-oxo-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

: 98875-19-5
(2R,3S,4S,4aS,8aR)-2-Benzenesulfonyloxymethyl-4-dimethylcarbamoylmethyl-3-hydroxy-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: camphorsulfonic acid (CSA)

2: 95 percent / tetrahydrofuran

3: SOCl₂, pyridine / tetrahydrofuran

4: dimethylformamide

5: NaOMe / methanol

6: 88 percent / toluene / Heating

7: camphorsulfonic acid (CSA), MeOH

8: 83 percent / pyridine

With pyridine; methanol; thionyl chloride; camphor-10-sulfonic acid; sodium methylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00223a053

Reference yield:

: (4aR,8aR,9aR,10aR)-6-Methyl-9-oxo-2-phenyl-4,4a,5,9,9a,10a-hexahydro-8H-1,3,10-trioxa-anthracene-8a-carboxylic acid methyl ester

: 98875-19-5
(2R,3S,4S,4aS,8aR)-2-Benzenesulfonyloxymethyl-4-dimethylcarbamoylmethyl-3-hydroxy-7-methyl-4-vinyl-3,4,8,8a-tetrahydro-2H,5H-chromene-4a-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 95 percent / tetrahydrofuran

2: SOCl₂, pyridine / tetrahydrofuran

3: dimethylformamide

4: NaOMe / methanol

5: 88 percent / toluene / Heating

6: camphorsulfonic acid (CSA), MeOH

7: 83 percent / pyridine

With pyridine; methanol; thionyl chloride; camphor-10-sulfonic acid; sodium methylate; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00223a053