Benzoic acid (1R,2S)-3-benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-ylmethyl]-3-methyl-2-methylsulfanylmethoxy-butyl ester

Base Information

Chemical Name:Benzoic acid (1R,2S)-3-benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-ylmethyl]-3-methyl-2-methylsulfanylmethoxy-butyl ester
CAS No.:671792-49-7
Molecular Formula:C₃₉H₅₄N₂O₆S
Molecular Weight:678.934
Hs Code.:

Benzoic acid (1R,2S)-3-benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-ylmethyl]-3-methyl-2-methylsulfanylmethoxy-butyl ester

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Chemical Property of Benzoic acid (1R,2S)-3-benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-ylmethyl]-3-methyl-2-methylsulfanylmethoxy-butyl ester

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Technology Process of Benzoic acid (1R,2S)-3-benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-ylmethyl]-3-methyl-2-methylsulfanylmethoxy-butyl ester

There total 14 articles about Benzoic acid (1R,2S)-3-benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-ylmethyl]-3-methyl-2-methylsulfanylmethoxy-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: (2R,3S)-4-Benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-yl]-4-methyl-3-methylsulfanylmethoxy-pentan-2-ol

: 671792-49-7
Benzoic acid (1R,2S)-3-benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-ylmethyl]-3-methyl-2-methylsulfanylmethoxy-butyl ester

Guidance literature:: With dmap; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1002/hlca.200390328

Reference yield:

: 139629-93-9
(2R,3R)-1,2-O-isopropylidene-4-methyl-4-pentene-1,2,3-triol

: 671792-49-7
Benzoic acid (1R,2S)-3-benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-ylmethyl]-3-methyl-2-methylsulfanylmethoxy-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 91 percent / O₃; PPh₃ / CH₂Cl₂ / 1.5 h / -78 °C

2: 90 percent / tetrahydrofuran; diethyl ether / 1 h / 20 °C

3: 58 percent / AcOH; Ac₂O / 38 h / 20 °C

4: 96 percent / NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

5: 90 percent / (+)-camphorsulfonic acid / methanol; H₂O / 2.5 h / 65 °C

6: 91 percent / NaH; 1-tosyl-1H-imidazole / tetrahydrofuran / -78 - 0 °C / 2.2 Torr

7: LiNEt₂; DMPU; chiral octahydronaphthalene dimethylhydrazone / tetrahydrofuran; hexane / 17 h / -40 - 65 °C

8: DMAP / CH₂Cl₂ / 18 h / 20 °C

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; chiral octahydronaphthalene dimethylhydrazone; lithium diethylamide; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; ozone; acetic acid; (+)-10-camphorsulfonic acid; triphenylphosphine; N-tosylimidazole; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water;
DOI:10.1002/hlca.200390328

Reference yield:

: 83657-30-1
(+)-(1S)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-1-hydroxypropan-2-one

: 671792-49-7
Benzoic acid (1R,2S)-3-benzyloxy-1-[(1R,3aR,9aS,9bS)-7-(dimethyl-hydrazono)-1-methoxy-9a,9b-dimethyl-1,3,3a,4,5,7,8,9,9a,9b-decahydro-naphtho[1,2-c]furan-6-ylmethyl]-3-methyl-2-methylsulfanylmethoxy-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / tetrahydrofuran; diethyl ether / 1 h / 20 °C

2: 58 percent / AcOH; Ac₂O / 38 h / 20 °C

3: 96 percent / NaH; Bu₄NI / tetrahydrofuran / 0 - 20 °C

4: 90 percent / (+)-camphorsulfonic acid / methanol; H₂O / 2.5 h / 65 °C

5: 91 percent / NaH; 1-tosyl-1H-imidazole / tetrahydrofuran / -78 - 0 °C / 2.2 Torr

6: LiNEt₂; DMPU; chiral octahydronaphthalene dimethylhydrazone / tetrahydrofuran; hexane / 17 h / -40 - 65 °C

7: DMAP / CH₂Cl₂ / 18 h / 20 °C

With dmap; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; chiral octahydronaphthalene dimethylhydrazone; lithium diethylamide; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; acetic acid; (+)-10-camphorsulfonic acid; N-tosylimidazole; In tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; water;
DOI:10.1002/hlca.200390328