4-Azido-2-(trifluoromethyl)quinoline

Base Information

• Chemical Name: 4-Azido-2-(trifluoromethyl)quinoline
• CAS No.: 1701-33-3
• Molecular Formula: C₁₀H₅F₃N₄
• Molecular Weight: 238.172
• NSC Number: 128777
• DSSTox Substance ID: DTXSID70391992
• Wikidata: Q82189848
• Mol file: 1701-33-3.mol

Synonyms:1701-33-3;4-azido-2-(trifluoromethyl)quinoline;DTXSID70391992;NSC128777;NSC-128777

Chemical Property of 4-Azido-2-(trifluoromethyl)quinoline

Chemical Property:

• XLogP3: 4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 1
• Exact Mass: 238.04663066
• Heavy Atom Count: 17
• Complexity: 324

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=CC(=N2)C(F)(F)F)N=[N+]=[N-]

Technology Process of 4-Azido-2-(trifluoromethyl)quinoline

There total 2 articles about 4-Azido-2-(trifluoromethyl)quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-chloro-2-(trifluoromethyl)quinoline (1701-24-2) → 4-azido-2-trifluoromethylquinoline (1701-33-3)

Guidance literature:

With sodium azide; 15-crown-5; In butan-1-ol; at 150 ℃; for 4h;

DOI:10.1016/j.bmc.2010.06.071

Reference yield:

→ 4-azido-2-trifluoromethylquinoline (1701-33-3)

Guidance literature:

1) 4-Hydrazino-2-trifluormethyl-chinolin in 95percentig. A., konz. HCl; 2) wssr. NaNO2 / 30min;

Reference yield: 73.0%

4-azido-2-trifluoromethylquinoline (1701-33-3) → 4-amino-2-trifluoromethyl-quinoline (1700-93-2)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; for 3h;

DOI:10.1016/j.bmc.2010.06.071

upstream raw materials:

4-chloro-2-(trifluoromethyl)quinoline

Downstream raw materials:

4-amino-2-trifluoromethyl-quinoline