Technology Process of ethyl-2 methyl-8 phenyl-1 dehydro-1,2 pyrrolizidine
There total 4 articles about ethyl-2 methyl-8 phenyl-1 dehydro-1,2 pyrrolizidine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
bromine; triethylamine; triphenylphosphine;
In
acetonitrile;
1.) 0 deg C; 2.) 16 h, rt;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 35 percent / potassium hydride / tetrahydrofuran / 1.) 0 deg C, 2 h; 2.) rt, 14 h
2: 79 percent / aluminium chloride, lithium aluminium hydride / diethyl ether / 4 h / 0 °C
3: 1.) 9-BBN; 2.) H2O2, NaOH / 1.) THF,0 deg C; 8 h, 40 deg C; 2.) aq. EtOH, reflux, 14 h
4: 24 percent / triphenylphosphine/Br2, triethylamine / acetonitrile / 1.) 0 deg C; 2.) 16 h, rt
With
sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; aluminium trichloride; dihydrogen peroxide; bromine; potassium hydride; triethylamine; triphenylphosphine;
In
tetrahydrofuran; diethyl ether; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 79 percent / aluminium chloride, lithium aluminium hydride / diethyl ether / 4 h / 0 °C
2: 1.) 9-BBN; 2.) H2O2, NaOH / 1.) THF,0 deg C; 8 h, 40 deg C; 2.) aq. EtOH, reflux, 14 h
3: 24 percent / triphenylphosphine/Br2, triethylamine / acetonitrile / 1.) 0 deg C; 2.) 16 h, rt
With
sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; aluminium trichloride; dihydrogen peroxide; bromine; triethylamine; triphenylphosphine;
In
diethyl ether; acetonitrile;
