6-Cyclopropyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

Base Information

• Chemical Name: 6-Cyclopropyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester
• CAS No.: 161886-38-0
• Molecular Formula: C₂₆H₂₃N₇O₃
• Molecular Weight: 481.514
• Mol file: 161886-38-0.mol

Synonyms:

Chemical Property of 6-Cyclopropyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Cyclopropyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

There total 6 articles about 6-Cyclopropyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2-cyclopropyl acetate (53432-87-4) → 6-Cyclopropyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester (161886-38-0)

Guidance literature:

Multi-step reaction with 4 steps

1: t-BuOK / tetrahydrofuran / 3 h / Ambient temperature

2: acetic acid / ethanol / 12 h / Heating

3: NaH / dimethylformamide / 4 h / Ambient temperature

4: 1.) trimethyltin azide, 2.) 1N aq. HCl / 1.) xylene, 110 deg C, 24 h, 2.) ethanol, RT, 1 h

With hydrogenchloride; trimethyltin azide; potassium tert-butylate; sodium hydride; acetic acid; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.43.960

Reference yield:

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile (114772-54-2) → 6-Cyclopropyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester (161886-38-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / dimethylformamide / 4 h / Ambient temperature

2: 1.) trimethyltin azide, 2.) 1N aq. HCl / 1.) xylene, 110 deg C, 24 h, 2.) ethanol, RT, 1 h

With hydrogenchloride; trimethyltin azide; sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1248/cpb.43.960

Reference yield:

3-amino-4-pyrazolecarboxylic acid ethyl ester (6994-25-8,103259-35-4,19750-02-8) → 6-Cyclopropyl-7-oxo-4-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester (161886-38-0)

Guidance literature:

Multi-step reaction with 3 steps

1: acetic acid / ethanol / 12 h / Heating

2: NaH / dimethylformamide / 4 h / Ambient temperature

3: 1.) trimethyltin azide, 2.) 1N aq. HCl / 1.) xylene, 110 deg C, 24 h, 2.) ethanol, RT, 1 h

With hydrogenchloride; trimethyltin azide; sodium hydride; acetic acid; In ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.43.960

upstream raw materials:

4-(2'-Cyano-biphenyl-4-ylmethyl)-6-cyclopropyl-7-oxo-4,7-dihydro-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid ethyl ester

ethyl 2-cyclopropyl acetate

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

3-amino-4-pyrazolecarboxylic acid ethyl ester