Technology Process of 4-((2S,4R)-1-acetyl-2-methyl-4-(p-tolylamino)-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid
There total 9 articles about 4-((2S,4R)-1-acetyl-2-methyl-4-(p-tolylamino)-1,2,3,4-tetrahydroquinolin-6-yl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C27H28N2O3;
With
sodium hydroxide;
In
ethanol;
at 60 ℃;
for 1h;
With
acetic acid;
In
water;
pH=4 - 5;
DOI:10.1021/jm5010539
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine; copper diacetate / dichloromethane / 20 °C
2.1: sodium hydroxide / ethanol / 1 h / 60 °C
2.2: pH 4 - 5
With
copper diacetate; triethylamine; sodium hydroxide;
In
ethanol; dichloromethane;
1.1: |Chan-Lam Coupling;
DOI:10.1021/jm5010539
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: toluene / 12 h / 20 °C / Inert atmosphere
2.1: boron trifluoride diethyl etherate / tetrahydrofuran / 0.25 h / -5 °C / Inert atmosphere
2.2: 2 h / -5 °C / Inert atmosphere
3.1: pyridine / dichloromethane / 2 h / 0 °C
4.1: triethylamine; copper diacetate / dichloromethane / 20 °C
5.1: hydrogenchloride / methanol; water / 3 h / Reflux
6.1: L-Lactic acid / ethanol; water / 0.5 h / Reflux
6.2: 0.5 h
6.3: 0.33 h / Reflux; Resolution of racemate
7.1: triethylamine; copper diacetate / dichloromethane / 20 °C
8.1: sodium hydroxide / ethanol / 1 h / 60 °C
8.2: pH 4 - 5
With
pyridine; hydrogenchloride; L-Lactic acid; boron trifluoride diethyl etherate; copper diacetate; triethylamine; sodium hydroxide;
In
tetrahydrofuran; methanol; ethanol; dichloromethane; water; toluene;
4.1: |Chan-Lam Coupling / 7.1: |Chan-Lam Coupling;
DOI:10.1021/jm5010539
