7,8-Dimethoxy-2,3-dihydro-1H-4-quinolinone

Base Information

• Chemical Name: 7,8-Dimethoxy-2,3-dihydro-1H-4-quinolinone
• CAS No.: 436810-55-8
• Molecular Formula: C₁₁H₁₃NO₃
• Molecular Weight: 207.229
• DSSTox Substance ID: DTXSID30453449
• Nikkaji Number: J1.756.828K
• Wikidata: Q82274592
• Mol file: 436810-55-8.mol

Synonyms:7,8-Dimethoxy-2,3-dihydro-1H-4-quinolinone;436810-55-8;7,8-dimethoxy-2,3-dihydro-1H-quinolin-4-one;DTXSID30453449;MFCD11501287;7,8-Dimethoxy-1,2-dihydroquinoline-4(3H)-one;A918072

Chemical Property of 7,8-Dimethoxy-2,3-dihydro-1H-4-quinolinone

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• XLogP3: 1.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 207.08954328
• Heavy Atom Count: 15
• Complexity: 244

Purity/Quality:

97% ^*data from raw suppliers

7,8-Dimethoxy-2,3-dihydro-1H-4-quinolinone 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=C(C2=C(C=C1)C(=O)CCN2)OC

Technology Process of 7,8-Dimethoxy-2,3-dihydro-1H-4-quinolinone

There total 6 articles about 7,8-Dimethoxy-2,3-dihydro-1H-4-quinolinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

3-(2,3-dimethoxyphenylamino)propionic acid (436810-54-7) → 7,8-dimethoxy-2,3-dihydro-1H-quinolin-4-one (436810-55-8)

Guidance literature:

With PPA; at 90 ℃; for 0.333333h;

DOI:10.1021/jo011057m

Reference yield: 70.0%

3-[(2,3-dimethoxyphenyl)-(toluene-4-sulfonyl)-amino]-propionic acid (1036766-03-6) → 7,8-dimethoxy-2,3-dihydro-1H-quinolin-4-one (436810-55-8) + 7,8-dimethoxy-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-quinolin-4-one (1036766-04-7)

Guidance literature:

With tin(IV) chloride; at 0 ℃;

DOI:10.1016/j.tet.2008.03.036

Reference yield: 20.0%

3-[(2,3-dimethoxyphenyl)-(toluene-4-sulfonyl)-amino]-propionic acid (1036766-03-6) → 7,8-dimethoxy-2,3-dihydro-1H-quinolin-4-one (436810-55-8)

Guidance literature:

With PPA; at 90 ℃;

DOI:10.1016/j.tet.2008.03.036

upstream raw materials:

3-(2,3-dimethoxyphenylamino)propionic acid

2,3-dimethoxybenzoic acid

2,3-dimethoxyaniline

2,3-dimethoxyphenylcarbamic acid ethyl ester