2,3-Dimethoxyaniline

Base Information

• Chemical Name: 2,3-Dimethoxyaniline
• CAS No.: 6299-67-8
• Molecular Formula: C8H11NO2
• Molecular Weight: 153.181
• Hs Code.: 29214200
• European Community (EC) Number: 675-143-0
• NSC Number: 44873
• DSSTox Substance ID: DTXSID30286335
• Nikkaji Number: J175.236G
• Wikidata: Q72467596
• Mol file: 6299-67-8.mol

Synonyms:2,3-Dimethoxyaniline;6299-67-8;(2,3-dimethoxyphenyl)amine;2,3-dimethoxy-phenylamine;Benzenamine, 2,3-dimethoxy-;MFCD00180769;NSC44873;2,3-Dimethoxyaniline #;2,3-bis(methyloxy)aniline;6-methoxy-2-amino anisole;SCHEMBL210128;Amino-brenzkatechin-dimethylather;HEZIOZBMPKPOER-UHFFFAOYSA-;DTXSID30286335;2,3-dimethoxyaniline, AldrichCPR;AMY28016;NSC-44873;STK501473;AKOS000314057;CS-W016280;SB75740;AS-10695;SY030638;BB 0257834;D2284;FT-0648042;EN300-99105;J-507027;F5608-0070;InChI=1/C8H11NO2/c1-10-7-5-3-4-6(9)8(7)11-2/h3-5H,9H2,1-2H3

Chemical Property of 2,3-Dimethoxyaniline

Chemical Property:

• Refractive Index: 1.5630-1.5650
• Boiling Point: 93 °C / 1.4mmHg
• PKA: 4.12±0.10(Predicted)
• PSA: 44.48000
• Density: 1.14 g/cm³
• LogP: 1.86720
• Storage Temp.: Refrigerator
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 153.078978594
• Heavy Atom Count: 11
• Complexity: 119

Purity/Quality:

97% ^*data from raw suppliers

2,3-Dimethoxyaniline ^*data from reagent suppliers

Safty Information:

• Statements: 20/21/22-36/37/38-36/38
• Safety Statements: 26-36/37/39-51-20/21

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=C1OC)N
• Uses: 2,3-Dimethoxyaniline can be used for composition of hair dye consisting of a monoaminobenzene and a metal catalyst.

Technology Process of 2,3-Dimethoxyaniline

There total 20 articles about 2,3-Dimethoxyaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-hydroxy-2,3-dimethoxybenzamide (343773-22-8) → 2,3-dimethoxyaniline (6299-67-8)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 90 ℃; for 2h;

DOI:10.1039/b822806j

Reference yield: 96.0%

benzyl 2,3-dimethoxyphenylcarbamate (182205-44-3) → 2,3-dimethoxyaniline (6299-67-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethyl acetate; for 6h; under 1551.49 Torr;

DOI:10.1021/jm801335z

Reference yield: 94.0%

tert-butyl 2,3-dimethoxyphenylcarbamate → 2,3-dimethoxyaniline (6299-67-8)

Guidance literature:

With hydrogenchloride; In methanol; at 20 ℃; Heating;

upstream raw materials:

2,3-dimethoxybenzamide

3,4-dimethoxyanthranilic acid

3-nitroveratrole

1,2-dimethoxybenzene

Downstream raw materials:

N-(2,3-dimethoxy-phenyl)-anthranilic acid

3-chloro-N-(2,3-dimethoxyphenyl)benzothiophene-2-carboxamide

sodium 2,3-dimethoxyphenylhydrazinesulfonate

3-nitrosoveratrole