5-(3-chloro-4-methoxybenzyl)-4-phenyl-3-(2-chlorophenethyl)sulfanyl-4H-1,2,4-triazole

Base Information

• Chemical Name: 5-(3-chloro-4-methoxybenzyl)-4-phenyl-3-(2-chlorophenethyl)sulfanyl-4H-1,2,4-triazole
• CAS No.: 1616590-79-4
• Molecular Formula: C₂₄H₂₁Cl₂N₃OS
• Molecular Weight: 470.422
• Mol file: 1616590-79-4.mol

Synonyms:

Chemical Property of 5-(3-chloro-4-methoxybenzyl)-4-phenyl-3-(2-chlorophenethyl)sulfanyl-4H-1,2,4-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(3-chloro-4-methoxybenzyl)-4-phenyl-3-(2-chlorophenethyl)sulfanyl-4H-1,2,4-triazole

There total 2 articles about 5-(3-chloro-4-methoxybenzyl)-4-phenyl-3-(2-chlorophenethyl)sulfanyl-4H-1,2,4-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

2-chlorophenylethyl chloride (1005-06-7) + 5-(3-chloro-4-methoxybenzyl)-4-phenyl-4H-1,2,4-triazole-3-thiol (714280-58-7) → 5-(3-chloro-4-methoxybenzyl)-4-phenyl-3-(2-chlorophenethyl)sulfanyl-4H-1,2,4-triazole (1616590-79-4)

Guidance literature:

5-(3-chloro-4-methoxybenzyl)-4-phenyl-4H-1,2,4-triazole-3-thiol; With potassium hydroxide; In ethanol; Reflux;

2-chlorophenylethyl chloride; In ethanol; Reflux;

DOI:10.1134/S1070428014050194

Reference yield:

C16H16ClN3O2S (831184-16-8) → 5-(3-chloro-4-methoxybenzyl)-4-phenyl-3-(2-chlorophenethyl)sulfanyl-4H-1,2,4-triazole (1616590-79-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / water / 2 h / Reflux

2.1: potassium hydroxide / ethanol / Reflux

2.2: Reflux

With potassium hydroxide; In ethanol; water;

DOI:10.1134/S1070428014050194

upstream raw materials:

2-chlorophenylethyl chloride

5-(3-chloro-4-methoxybenzyl)-4-phenyl-4H-1,2,4-triazole-3-thiol

C₁₆H₁₆ClN₃O₂S

Refernces