1005-06-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(2-Chloroethyl)-2-chlorobenzene is used as a chemical intermediate for the synthesis of pharmaceuticals, contributing to the development of new medications due to its reactive chemical properties that facilitate the creation of diverse molecular structures.
Used in Agrochemical Industry:
Similarly, in the agrochemical sector, 1-(2-Chloroethyl)-2-chlorobenzene serves as a crucial intermediate, playing a part in the production of various agrochemicals that are vital for agricultural productivity and pest control.
Used as an Industrial Solvent:
1-(2-Chloroethyl)-2-chlorobenzene is utilized as a solvent in several industrial processes, capitalizing on its ability to dissolve a wide range of substances, which is essential for numerous manufacturing and chemical reaction procedures.

Upstream product

• 19819-95-5 2-(2-chlorophenyl)-1-ethanol 
• 89-96-3 1-chloro-2-ethylbenzene 
• 40061-54-9 2-chlorophenylacetic acid ethyl ester 
• 694-87-1 benzocyclobutene 

Downstream Products

• 92328-85-3 2-Dipropylamino-1-<2-chlor-phenyl>-aethan 
• 64008-49-7 4-(2-Chloro-phenyl)-2-(2,4-dichloro-phenyl)-butyric acid methyl ester 
• 517914-33-9 1-{2-[2-(1-hydroxycyclohexyl)phenyl]ethyl}-1-cyclohexanol 
• 1616590-79-4 5-(3-chloro-4-methoxybenzyl)-4-phenyl-3-(2-chlorophenethyl)sulfanyl-4H-1,2,4-triazole 
• 7315-17-5 3-(2-chloro-phenyl)-propionitrile 
• 71721-13-6 1-chloro-2-<2-(phenylsulfonyl)ethyl>benzene 
• 71721-16-9 1-(phenylsulfonyl)benzocyclobutene 
• 92165-82-7 1-Phenylmercapto-2-<2-chlor-phenyl>-ethan 

Relevant academic research and scientific papers

Dihydroxy pyrimidine compound and use thereof

The invention provides a dihydroxy pyrimidine compound, its structural general formula is: Wherein R1 In order to contain the substituent of the aryl, heterocyclic or containing substituent is C1 - C6 alkyl; R2 Is C1 - C6 alkyl, C1 - C6 alkyl aryl, C1 - C6 alkyl heterocyclic group or a hydrogen atom; x, y each is between 0 - 6 is any natural number. The invention also provides a two-hydroxy pyrimidine compounds in the preparation of anti-influenza virus in the application. The present invention provides a dihydroxy pyrimidine compounds to the influenza virus activity has better inhibition, can remarkably reduce the toxicity of the influenza virus, and cytotoxicity is relatively low, thus can such compounds for the preparation of anti-influenza virus drugs.

Ketone-catalyzed photochemical C(sp3)–H chlorination

Photoexcited arylketones catalyze the direct chlorination of C(sp3)–H groups by N- chlorosuccinimide. Acetophenone is the most effective catalyst for functionalization of unactivated C–H groups while benzophenone provides better yields for benzylic C–H functionalization. Activation of both acetophenone and benzophenone can be achieved by irradiation with a household compact fluorescent lamp. This light-dependent reaction provides a better control of the reaction as compared to the traditional chlorination methods that proceed through a free radical chain propagation mechanism.

Pyrrolo[2,3-d] pyrimidines as antiviral agents

This invention relates to a novel class of 4,5,6,7-substituted non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidines which exhibit both significantly lower levels of cytotoxicity and superior antiviral activity than known nucleoside, non-nucleoside, and non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidine derivatives, particularly against human DNA viruses such as cytomegalovirus (HCMV) and herpes simplex virus type 1 (HSV-1). These compounds are represented by the following formula: wherein: R4is —NR1R2or oxo; R5is —CN, or —CSNR1R2, or —CONR1R2; R6is —H, or halo, or —NR1R2; wherein R1and R2are independently —H or an aliphatic group; and R7is of the formula R3—Ar, wherein R3is an aliphatic group and Ar is an unsubstituted aryl or an aryl independently substituted with halo, nitro, amino, or aliphatic groups; provided that when R5is a —CN or —CSNH2, and R6is a —H or —NH2, and Ar is a —C6H5or a phenyl substituted with only one aliphatic group, R3is an aliphatic group other than methyl such that —R3— is not a —CH2—; and pharmaceutically acceptable salts, prodrugs and derivatives thereof.

Lithiophenylalkyllithiums: New dilithium reagents having both sp2- and sp3-hybridised remote carbanionic centres

The reaction of chloro-(2-chloroethyl)benzenes (1), 4-chloro-(3-chloropropyl)benzene (3) or 4-chlorophenyl chloromethyl ether (5) with lithium power using naphthalene as the electron shuttle (8 mol%) in the presence of different carbonyl compounds [Busub

A new synthesis of 3-substituted-1H-indenes through reaction of o-(β-magnesioalkyl)phenylmagnesium dihalides with carboxylate esters

A new synthesis of 3-substituted-1H-indenes has been developed through the reaction of o-(β-magnesioalkyl)phenylmagnesium dihalides with carboxylate esters, followed by dehydration of the intermediate 1-substituted-1-indanols. Di-Grignard reagents allowing the synthesis of 3-substituted-, 2-methyl-3-substituted-, and 4-methyl-3-substituted-1H-indenes have been prepared, with overall yields for the two-step sequence ranging from 45 to 95%.