C₂₅H₂₈N₄O₃

Base Information

• Chemical Name: C₂₅H₂₈N₄O₃
• CAS No.: 1535169-03-9
• Molecular Formula: C₂₅H₂₈N₄O₃
• Molecular Weight: 432.522
• Mol file: 1535169-03-9.mol

Synonyms:

Chemical Property of C₂₅H₂₈N₄O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₅H₂₈N₄O₃

There total 4 articles about C₂₅H₂₈N₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-amino-4-(methoxycarbonyl)phenyl)boronic acid hydrochloride salt (380430-55-7) + 1-(2-(benzyloxy)ethyl)-2-butyl-5-iodo-1H-imidazole-4-carbonitrile (1535168-92-3) → C25H28N4O3 (1535169-03-9)

Guidance literature:

With palladium(II) catalyst; In water; at 25 - 100 ℃; for 3h; Inert atmosphere; Alkaline conditions;

DOI:10.1021/jm4004957

Reference yield:

5-amino-1-(2-(benzyloxy)ethyl)-2-butyl-1H-imidazole-4-carbonitrile (1535168-81-0) → C25H28N4O3 (1535169-03-9)

Guidance literature:

Multi-step reaction with 2 steps

1: isopentyl nitrite; diiodomethane / chloroform / 0.5 h / 80 °C

2: palladium(II) catalyst / water / 3 h / 25 - 100 °C / Inert atmosphere; Alkaline conditions

With diiodomethane; isopentyl nitrite; In chloroform; water; 2: |Suzuki-Miyaura Coupling;

DOI:10.1021/jm4004957

Reference yield:

O-benzylethanolamine (38336-04-8) → C25H28N4O3 (1535169-03-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0.5 h / 25 °C

1.2: 3 h / Reflux

1.3: 15 h / 25 °C

2.1: isopentyl nitrite; diiodomethane / chloroform / 0.5 h / 80 °C

3.1: palladium(II) catalyst / water / 3 h / 25 - 100 °C / Inert atmosphere; Alkaline conditions

With diiodomethane; triethylamine; isopentyl nitrite; In tetrahydrofuran; chloroform; water; 3.1: |Suzuki-Miyaura Coupling;

DOI:10.1021/jm4004957

upstream raw materials:

trimethyl orthovalerate

5-amino-1-(2-(benzyloxy)ethyl)-2-butyl-1H-imidazole-4-carbonitrile

O-benzylethanolamine

(2-amino-4-(methoxycarbonyl)phenyl)boronic acid hydrochloride salt

Downstream raw materials:

4-amino-1-(2-(benzyloxy)ethyl)-2-butyl-7-methoxycarbonyl-1H-imidazo[4,5-c]quinoline