(E)-4-fluoro-N-(6-((3-(2-hydroxypropan-2-yl)azetidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

Base Information

Chemical Name:(E)-4-fluoro-N-(6-((3-(2-hydroxypropan-2-yl)azetidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide
CAS No.:1357921-05-1
Molecular Formula:C₃₁H₄₀FN₅O₃
Molecular Weight:549.689
Hs Code.:

(E)-4-fluoro-N-(6-((3-(2-hydroxypropan-2-yl)azetidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

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Chemical Property of (E)-4-fluoro-N-(6-((3-(2-hydroxypropan-2-yl)azetidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

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Technology Process of (E)-4-fluoro-N-(6-((3-(2-hydroxypropan-2-yl)azetidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

There total 5 articles about (E)-4-fluoro-N-(6-((3-(2-hydroxypropan-2-yl)azetidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.4%

: 1357923-33-1
2-(azetidin-3-yl)propan-2-ol hydrochloride

: C₂₅H₂₈ClFN₄O₂

: 1357921-05-1,1388225-76-0
(E)-4-fluoro-N-(6-((3-(2-hydroxypropan-2-yl)azetidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃;
DOI:10.1021/jm3005866

Reference yield:

: 1357920-83-2,1388225-59-9
(E)-4-fluoro-N-(6-(hydroxymethyl)-1-( (1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

: 1357921-05-1,1388225-76-0
(E)-4-fluoro-N-(6-((3-(2-hydroxypropan-2-yl)azetidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; acetonitrile;
DOI:10.1021/jm3005866

Reference yield:

: 403-43-0
4-fluorobenzoyl chloride

: 1357921-05-1,1388225-76-0
(E)-4-fluoro-N-(6-((3-(2-hydroxypropan-2-yl)azetidin-1-yl)methyl)-1-((1s,4s)-4-(isopropylcarbamoyl)cyclohexyl)-1H-benzo[d]imidazol-2(3H)-ylidene)benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetone / 7 h / 50 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 60 °C

3: thionyl chloride / dichloromethane / 0.5 h / 0 - 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

With thionyl chloride; 1,8-diazabicyclo[5.4.0]undec-7-ene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; acetone; acetonitrile;
DOI:10.1021/jm3005866