N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine methyl ester

Base Information

Chemical Name:N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine methyl ester
CAS No.:133628-29-2
Molecular Formula:C₂₂H₂₆N₂O₄
Molecular Weight:382.459
Hs Code.:
DSSTox Substance ID:DTXSID301189917

Synonyms:SCHEMBL12972620;DTXSID301189917;N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine methyl ester;133628-29-2

Suppliers and Price of N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine methyl ester

Chemical Property:

XLogP3:3.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:10
Exact Mass:382.18925731
Heavy Atom Count:28
Complexity:505

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC(=O)C(CCCCNC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)N
Isomeric SMILES:COC(=O)[C@H](CCCCNC(=O)OCC1C2=CC=CC=C2C3=CC=CC=C13)N

Technology Process of N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine methyl ester

There total 1 articles about N6-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-lysine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 849752-39-2
6-(9H-fluoren-9-ylmethoxycarbonylamino)-2-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-hexanoic acid methyl ester

: 84624-28-2,212140-39-1
N-(fluorenyl-9-methoxycarbonyl)-L-lysine

: 133628-29-2
N_ε-<(fluoren-9-ylmethoxy)carbonyl>lysine methyl ester

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; water; at 0 ℃; for 0.0833333h;
DOI:10.1016/j.tet.2004.12.052

Reference yield:

: 1142-20-7
N-Cbz-Ala

: 133628-29-2
N_ε-<(fluoren-9-ylmethoxy)carbonyl>lysine methyl ester

: C₃₃H₃₇N₃O₇

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/acs.jmedchem.7b01241

Reference yield:

: 133628-29-2
N_ε-<(fluoren-9-ylmethoxy)carbonyl>lysine methyl ester

: Ac-Phe-Leu-Pro-Lys(Fmoc)-OMe

Guidance literature:: Multi-step reaction with 5 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 18 h / 20 °C

4: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

5: triethylamine / dichloromethane / 20 °C

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;