4,5-bis(4-chlorophenyl)-2-methyloxazole

Base Information

• Chemical Name: 4,5-bis(4-chlorophenyl)-2-methyloxazole
• CAS No.: 92794-43-9
• Molecular Formula: C₁₆H₁₁Cl₂NO
• Molecular Weight: 304.175
• Mol file: 92794-43-9.mol

Synonyms:

Chemical Property of 4,5-bis(4-chlorophenyl)-2-methyloxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-bis(4-chlorophenyl)-2-methyloxazole

There total 5 articles about 4,5-bis(4-chlorophenyl)-2-methyloxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

bis(4-chlorophenyl)acetylene (1820-42-4) + acetonitrile (75-05-8,26809-02-9) → 4,5-bis(4-chlorophenyl)-2-methyloxazole (92794-43-9)

Guidance literature:

acetonitrile; With tetrabutylammonium tetrafluoroborate; water; iodine; acetic acid; for 2.68333h; Electrolysis;

bis(4-chlorophenyl)acetylene; In water; for 1.08333h; Electrolysis;

DOI:10.1002/chem.202004140

Reference yield:

1-(4-chlorophenyl)-2-trimethylsilylacetylene (78704-49-1) → 4,5-bis(4-chlorophenyl)-2-methyloxazole (92794-43-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: potassium carbonate / methanol; dichloromethane / 1 h / Inert atmosphere

2.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / Inert atmosphere

3.1: tetrabutylammonium tetrafluoroborate; iodine; acetic acid; water / 2.68 h / Electrolysis

3.2: 1.08 h / Electrolysis

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutylammonium tetrafluoroborate; water; iodine; potassium carbonate; acetic acid; triethylamine; In tetrahydrofuran; methanol; dichloromethane; 2.1: |Sonogashira Cross-Coupling;

DOI:10.1002/chem.202004140

Reference yield:

4-n-chlorophenylacetylene (873-73-4) → 4,5-bis(4-chlorophenyl)-2-methyloxazole (92794-43-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / Inert atmosphere

2.1: tetrabutylammonium tetrafluoroborate; iodine; acetic acid; water / 2.68 h / Electrolysis

2.2: 1.08 h / Electrolysis

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutylammonium tetrafluoroborate; water; iodine; acetic acid; triethylamine; In tetrahydrofuran; 1.1: |Sonogashira Cross-Coupling;

DOI:10.1002/chem.202004140

upstream raw materials:

1-(4-chlorophenyl)-2-trimethylsilylacetylene

4-n-chlorophenylacetylene

bis(4-chlorophenyl)acetylene

acetonitrile