1-ethyl-11-[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate

Base Information

• Chemical Name: 1-ethyl-11-[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate
• CAS No.: 1345614-72-3
• Molecular Formula: C₂F₃O₂*C₃₁H₃₃F₃N₃O₄S
• Molecular Weight: 713.698
• Mol file: 1345614-72-3.mol

Synonyms:

Chemical Property of 1-ethyl-11-[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-ethyl-11-[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate

There total 8 articles about 1-ethyl-11-[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxy-1,2,3,4-tetrahydroquinoline (19500-61-9) → 1-ethyl-11-[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate (1345614-72-3)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 65 °C

2: sulfuric acid / methanol; water / 1 h / 20 °C

3: acetic acid / 1.83 h / 80 °C

With sulfuric acid; potassium carbonate; In methanol; water; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/ol202619f

Reference yield:

3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester (1345614-60-9) → 1-ethyl-11-[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate (1345614-72-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium iodide / acetone / Reflux

2: potassium carbonate / N,N-dimethyl-formamide / 65 °C

3: sulfuric acid / methanol; water / 1 h / 20 °C

4: acetic acid / 1.83 h / 80 °C

With sulfuric acid; potassium carbonate; sodium iodide; In methanol; water; acetic acid; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ol202619f

Reference yield:

3-(7-methoxy-3,4-dihydro-2H-quinolin-1-yl)propane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester (1345614-64-3) → 1-ethyl-11-[3-(2,2,2-trifluoro-1-phenylethoxysulfonyl)propyl]-3,4,8,9,10,11-hexahydro-2H-13-oxa-6,11-diaza-1-azonia-pentacene trifluoroacetate (1345614-72-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / methanol; water / 1 h / 20 °C

2: acetic acid / 1.83 h / 80 °C

With sulfuric acid; In methanol; water; acetic acid;

DOI:10.1021/ol202619f

upstream raw materials:

7-methoxy-1,2,3,4-tetrahydroquinoline

3-chloropropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

3-iodopropane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester

3-(7-methoxy-3,4-dihydro-2H-quinolin-1-yl)propane-1-sulfonic acid 2,2,2-trifluoro-1-phenylethyl ester