Technology Process of methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-6-naphthylacetate
There total 6 articles about methyl 7-(2-chloro-3-methoxybenzoyl)-1,2,3,4-tetrahydro-5,8-dimethoxy-6-naphthylacetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
trifluoroacetic anhydride;
at 60 ℃;
for 144h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 75 percent / TiCl4 / CH2Cl2 / 0.25 h / 0 °C
2: 92 percent / LiAlH4 / diethyl ether / 1 h / 50 °C
3: PBr3 / diethyl ether / 0.5 h / 0 °C
4: ethanol; H2O / 2 h / Heating
5: 89 percent / 10M NaOH / ethanol / 7.5 h / Heating
6: 95 percent / thionyl chloride / 3 h / Ambient temperature
7: 49 percent / trifluoroacetic anhydride / 144 h / 60 °C
With
sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; phosphorus tribromide; titanium tetrachloride; trifluoroacetic anhydride;
In
diethyl ether; ethanol; dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1: PBr3 / diethyl ether / 0.5 h / 0 °C
2: ethanol; H2O / 2 h / Heating
3: 89 percent / 10M NaOH / ethanol / 7.5 h / Heating
4: 95 percent / thionyl chloride / 3 h / Ambient temperature
5: 49 percent / trifluoroacetic anhydride / 144 h / 60 °C
With
sodium hydroxide; thionyl chloride; phosphorus tribromide; trifluoroacetic anhydride;
In
diethyl ether; ethanol; water;
