(S)-6-(4-Methoxy-benzyl)-1,4-dimethyl-azepan-4-ol

Base Information

Chemical Name:(S)-6-(4-Methoxy-benzyl)-1,4-dimethyl-azepan-4-ol
CAS No.:845537-38-4
Molecular Formula:C₁₆H₂₅NO₂
Molecular Weight:263.38
Hs Code.:

Synonyms:

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Chemical Property of (S)-6-(4-Methoxy-benzyl)-1,4-dimethyl-azepan-4-ol

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Technology Process of (S)-6-(4-Methoxy-benzyl)-1,4-dimethyl-azepan-4-ol

There total 13 articles about (S)-6-(4-Methoxy-benzyl)-1,4-dimethyl-azepan-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 63559-26-2
2-(p-methoxybenzyl)propane-1,3-diol

: 845537-38-4
(S)-6-(4-Methoxy-benzyl)-1,4-dimethyl-azepan-4-ol

Guidance literature:: Multi-step reaction with 11 steps

1: 96 percent / 2,6-di-tert-butyl-p-cresole, Lipase PS / diisopropyl ether; H₂O / 1.5 h / Ambient temperature

2: 97 percent / pyridinium p-tosylate / CH₂Cl₂ / 3 h / Ambient temperature

3: 82 percent / K₂CO₃ / methanol; H₂O / 1.5 h / Ambient temperature

4: 88 percent / 4-dimethylaminopyridine, pyridine / CH₂Cl₂ / 15 h

5: 86 percent / dimethylsulfoxide / 24 h / 80 - 90 °C

6: 97 percent / TsOH / methanol / 1.5 h / Ambient temperature

7: 80 percent / aq. 2M-NaOH / 3.5 h / Heating

8: ZnCl₂, HCl / ethanol

9: K₂CO₃, NaI / chlorobenzene / Heating

10: a.) NaH (60percent); 2.) 6N HCl / 1.) mineral oil, xylene, reflux; 2.) reflux

11: LiBr / tetrahydrofuran; diethyl ether / Ambient temperature

With pyridine; hydrogenchloride; dmap; sodium hydroxide; Lipase PS; 2,6-di-tert-butyl-4-methyl-phenol; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; sodium iodide; lithium bromide; zinc(II) chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; di-isopropyl ether; water; dimethyl sulfoxide; chlorobenzene;
DOI:10.3987/COM-95-7232

Reference yield:

: 824-94-2
p-methoxybenzyl chloride

: 845537-38-4
(S)-6-(4-Methoxy-benzyl)-1,4-dimethyl-azepan-4-ol

Guidance literature:: Multi-step reaction with 13 steps

1: 74 percent / 1.) sodium hydride / 1.) mineral oil, THF, r.t., 30 min; 2.) THF, 4 h, reflux

2: 95 percent / LiAlH₄ / tetrahydrofuran / 4 h / Heating

3: 96 percent / 2,6-di-tert-butyl-p-cresole, Lipase PS / diisopropyl ether; H₂O / 1.5 h / Ambient temperature

4: 97 percent / pyridinium p-tosylate / CH₂Cl₂ / 3 h / Ambient temperature

5: 82 percent / K₂CO₃ / methanol; H₂O / 1.5 h / Ambient temperature

6: 88 percent / 4-dimethylaminopyridine, pyridine / CH₂Cl₂ / 15 h

7: 86 percent / dimethylsulfoxide / 24 h / 80 - 90 °C

8: 97 percent / TsOH / methanol / 1.5 h / Ambient temperature

9: 80 percent / aq. 2M-NaOH / 3.5 h / Heating

10: ZnCl₂, HCl / ethanol

11: K₂CO₃, NaI / chlorobenzene / Heating

12: a.) NaH (60percent); 2.) 6N HCl / 1.) mineral oil, xylene, reflux; 2.) reflux

13: LiBr / tetrahydrofuran; diethyl ether / Ambient temperature

With pyridine; hydrogenchloride; dmap; sodium hydroxide; lithium aluminium tetrahydride; Lipase PS; 2,6-di-tert-butyl-4-methyl-phenol; pyridinium p-toluenesulfonate; sodium hydride; potassium carbonate; toluene-4-sulfonic acid; sodium iodide; lithium bromide; zinc(II) chloride; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; di-isopropyl ether; water; dimethyl sulfoxide; chlorobenzene;
DOI:10.3987/COM-95-7232

Reference yield:

: 174417-87-9
(S)-4-hydroxy-3-(p-methoxybenzyl)butyronitrile

: 845537-38-4
(S)-6-(4-Methoxy-benzyl)-1,4-dimethyl-azepan-4-ol

Guidance literature:: Multi-step reaction with 5 steps

1: 80 percent / aq. 2M-NaOH / 3.5 h / Heating

2: ZnCl₂, HCl / ethanol

3: K₂CO₃, NaI / chlorobenzene / Heating

4: a.) NaH (60percent); 2.) 6N HCl / 1.) mineral oil, xylene, reflux; 2.) reflux

5: LiBr / tetrahydrofuran; diethyl ether / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium hydride; potassium carbonate; sodium iodide; lithium bromide; zinc(II) chloride; In tetrahydrofuran; diethyl ether; ethanol; chlorobenzene;
DOI:10.3987/COM-95-7232