(4S,5S,6S)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4,5-isopropylidene-3-trifluoromethyl-5,6-dihydro-4H-1,2-oxazine

Base Information

• Chemical Name: (4S,5S,6S)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4,5-isopropylidene-3-trifluoromethyl-5,6-dihydro-4H-1,2-oxazine
• CAS No.: 956350-53-1
• Molecular Formula: C₁₈H₂₈F₃NO₄
• Molecular Weight: 379.42
• Mol file: 956350-53-1.mol

Synonyms:

Chemical Property of (4S,5S,6S)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4,5-isopropylidene-3-trifluoromethyl-5,6-dihydro-4H-1,2-oxazine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4S,5S,6S)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4,5-isopropylidene-3-trifluoromethyl-5,6-dihydro-4H-1,2-oxazine

There total 3 articles about (4S,5S,6S)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4,5-isopropylidene-3-trifluoromethyl-5,6-dihydro-4H-1,2-oxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(6S)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-3-trifluoromethyl-6H-1,2-oxazine → (4S,5S,6S)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4,5-isopropylidene-3-trifluoromethyl-5,6-dihydro-4H-1,2-oxazine (956350-53-1) + C15H24F3NO4

Guidance literature:

With ruthenium trichloride; sodium periodate; water; In ethyl acetate; acetonitrile; at 0 ℃; Title compound not separated from byproducts.;

DOI:10.1055/s-2007-983802

Reference yield:

C15H24F3NO4 + 2,2-dimethoxy-propane (77-76-9) → (4S,5S,6S)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4,5-isopropylidene-3-trifluoromethyl-5,6-dihydro-4H-1,2-oxazine (956350-53-1)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 4h;

DOI:10.1055/s-2007-983802

Reference yield:

C15H24F3NO4 + 2,2-dimethoxy-propane (77-76-9) → (4R,5R,6R)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4,5-isopropylidene-3-trifluoromethyl-5,6-dihydro-4H-1,2-oxazine + (4S,5S,6S)-6-[(1R,2S,5R)-2-isopropyl-5-methylcyclohexyloxy]-4,5-isopropylidene-3-trifluoromethyl-5,6-dihydro-4H-1,2-oxazine (956350-53-1)

Guidance literature:

With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 4h; Title compound not separated from byproducts.;

DOI:10.1055/s-2007-983802

upstream raw materials:

2,2-dimethoxy-propane