3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylic acid

Base Information

Chemical Name:3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylic acid
CAS No.:127267-57-6
Molecular Formula:C₁₁H₁₁NO₃
Molecular Weight:205.213
Hs Code.:
European Community (EC) Number:839-475-1
ChEMBL ID:CHEMBL4127772
Mol file:127267-57-6.mol

Synonyms:127267-57-6;3,3-dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylic acid;3,3-Dimethyl-2-oxoindoline-6-carboxylic acid;1H-Indole-6-carboxylic acid, 2,3-dihydro-3,3-dimethyl-2-oxo-;3,3-dimethyl-2-oxo-indoline-6-carboxylic acid;MFCD20483257;3,3-dimethyl-2-oxo-1H-indole-6-carboxylic acid;SCHEMBL3839942;CHEMBL4127772;ARPWLTXDPCHBLE-UHFFFAOYSA-N;CFA26757;AKOS030527676;CS-W004479;SB65871;PS-19265;SY203370;3,3-Dimethyl-2-oxoindoline-6-carboxylicacid;EN300-219951;P19007;Z1508956431;2,3-Dihydro-3,3-dimethyl-2-oxo-(1H)-indole-6-carboxylic acid

Suppliers and Price of 3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylicacid
25mg
$ 285.00

AK Scientific
3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylicacid
5g
$ 4348.00

AK Scientific
3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylicacid
100mg
$ 608.00

AK Scientific
3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylicacid
25mg
$ 341.00

AK Scientific
3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylicacid
2mg
$ 221.00

Total 5 raw suppliers

Chemical Property of 3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylic acid

Chemical Property:

XLogP3:1.2
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:205.07389321
Heavy Atom Count:15
Complexity:311

Purity/Quality:

99%, ^*data from raw suppliers

3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylicacid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1(C2=C(C=C(C=C2)C(=O)O)NC1=O)C

Technology Process of 3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylic acid

There total 3 articles about 3,3-Dimethyl-2-oxo-2,3-dihydro-1h-indole-6-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 3,3-dimethyl-2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

: 127267-57-6
3,3-dimethyl-2-oxoindolin-6-carboxylic acid

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 25 ℃; for 18h; Concentration;

Reference yield:

: 14192-26-8
2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester

: 74-88-4
methyl iodide

: 127267-57-6
3,3-dimethyl-2-oxoindolin-6-carboxylic acid

Guidance literature:: 2-oxo-2,3-dihydro-1H-indole-6-carboxylic acid methyl ester; methyl iodide; With sodium hydride; In N,N-dimethyl-formamide; at 22 ℃; for 17.5h;

With water; sodium hydroxide; In N,N-dimethyl-formamide; at 22 - 45 ℃; for 17h;

Reference yield:

: 158326-84-2
6-Bromo-3,3-dimethyl-2-oxo-indole

: 127267-57-6
3,3-dimethyl-2-oxoindolin-6-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 16 h / 100 °C / 7725.77 Torr / Inert atmosphere

2: water; hydrogenchloride / 18 h / 100 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; water; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide;