(2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-5-acetoxy-2-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-yl benzoate

Base Information

• Chemical Name: (2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-5-acetoxy-2-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-yl benzoate
• CAS No.: 1395097-62-7
• Molecular Formula: C₆₄H₇₂N₂O₁₄
• Molecular Weight: 1093.28

Synonyms:

Chemical Property of (2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-5-acetoxy-2-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-yl benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-5-acetoxy-2-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-yl benzoate

There total 5 articles about (2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-5-acetoxy-2-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C30H40N2O8 (1432499-64-3) + Ethyl 2-O-benzoyl-3,4,6-tri-O-benzyl-1-thio-β-D-glucopyranoside (169048-94-6) → (2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-5-acetoxy-2-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-yl benzoate (1395097-62-7)

Guidance literature:

With N-iodo-succinimide; trifluorormethanesulfonic acid; In dichloromethane; at -20 ℃; for 4h; Inert atmosphere; Schlenk technique;

DOI:10.1021/ol3023227

Reference yield:

(3R,4R,5S,6R)3-acetamido-6-methyl-4-(naphthalen-2-ylmethoxy)tetrahydro-2H-pyran-2,5-diyl diacetate → (2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-5-acetoxy-2-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-yl benzoate (1395097-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: boron trifluoride diethyl etherate / dichloromethane / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 4 h / 20 °C / Darkness; Schlenk technique

3: N-iodo-succinimide; trifluorormethanesulfonic acid / dichloromethane / 4 h / -20 °C / Inert atmosphere; Schlenk technique

With N-iodo-succinimide; trifluorormethanesulfonic acid; boron trifluoride diethyl etherate; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;

DOI:10.1021/ol3023227

Reference yield:

(2R,3S,4R,5R,6S)-5-acetamido-2-methyl-4-(naphthalen-2-ylmethoxy)-6-(p-tolylthio)tetrahydro-2H-pyran-3-yl acetate (1395097-59-2) → (2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-5-acetoxy-2-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-yl benzoate (1395097-62-7)

Guidance literature:

Multi-step reaction with 3 steps

1: N-iodo-succinimide; trifluorormethanesulfonic acid / dichloromethane; diethyl ether / 0 - 20 °C / Inert atmosphere; Schlenk technique

2: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 4 h / 20 °C / Darkness; Schlenk technique

3: N-iodo-succinimide; trifluorormethanesulfonic acid / dichloromethane / 4 h / -20 °C / Inert atmosphere; Schlenk technique

With N-iodo-succinimide; trifluorormethanesulfonic acid; water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In diethyl ether; dichloromethane;

DOI:10.1021/ol3023227

upstream raw materials:

(2R,3S,4R,5R,6S)-5-acetamido-2-methyl-4-(naphthalen-2-ylmethoxy)-6-(p-tolylthio)tetrahydro-2H-pyran-3-yl acetate

benzyl-(5-hydroxy-pentyl)-carbamic acid benzyl ester

(2R,3S,4R,5R,6R)-5-acetamido-6-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-2-methyl-4-(naphthalen-2-ylmethoxy)tetrahydro-2H-pyran-3-yl acetate

C₃₀H₄₀N₂O₈

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1395097-62-7 (2R,3R,4S,5R,6R)-2-(((2R,3R,4R,5S,6R)-3-acetamido-5-acetoxy-2-((5-(benzyl((benzyloxy)carbonyl)amino)pentyl)oxy)-6-methyltetrahydro-2H-pyran-4-yl)oxy)-4,5-bis(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-3-yl benzoate

Send

Send

Metric Ton KG G Pound L ML

Send

Send