C₆₃H₈₉N₁₁O₁₈

Base Information

• Chemical Name: C₆₃H₈₉N₁₁O₁₈
• CAS No.: 1632161-65-9
• Molecular Formula: C₆₃H₈₉N₁₁O₁₈
• Molecular Weight: 1288.46
• Mol file: 1632161-65-9.mol

Synonyms:

Chemical Property of C₆₃H₈₉N₁₁O₁₈

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₆₃H₈₉N₁₁O₁₈

There total 5 articles about C₆₃H₈₉N₁₁O₁₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

C66H93N11O18 (1632161-64-8) → C63H89N11O18 (1632161-65-9)

Guidance literature:

With Amberlyst^TM 15 resin; In methanol; at 20 ℃; for 4h;

DOI:10.1039/c4md00032c

Reference yield:

benzyl 4-[[7-(4-benzyloxy-4-oxo-butoxy)-6-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-2-naphthyl]oxy]butanoate (1632161-76-2) → C63H89N11O18 (1632161-65-9)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen; palladium on carbon / methanol; ethyl acetate / 24 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

3: Amberlyst^TM 15 resin / methanol / 4 h / 20 °C

With palladium on carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1039/c4md00032c

Reference yield:

3-bromonaphthalene-2,7-diol (102653-36-1) → C63H89N11O18 (1632161-65-9)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 50 °C

2: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 15 h / 110 °C / Schlenk technique; Inert atmosphere

3: hydrogen; palladium on carbon / methanol; ethyl acetate / 24 h / 20 °C

4: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

5: Amberlyst^TM 15 resin / methanol / 4 h / 20 °C

With palladium on carbon; hydrogen; palladium diacetate; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; 2: |Buchwald-Hartwig Coupling;

DOI:10.1039/c4md00032c

upstream raw materials:

3-bromonaphthalene-2,7-diol

benzyl 4-[[7-(4-benzyloxy-4-oxo-butoxy)-6-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-2-naphthyl]oxy]butanoate

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester

4-[[6-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-7-(4-hydroxy-4-oxo-butoxy)-2-naphtyl]oxy]butanoic acid