1H-Indole, 5-bromo-1-(4-fluorophenyl)-3-(4-piperidinyl)-

Base Information

Chemical Name:1H-Indole, 5-bromo-1-(4-fluorophenyl)-3-(4-piperidinyl)-
CAS No.:139718-50-6
Molecular Formula:C19H18BrFN2
Molecular Weight:373.268
Hs Code.:
DSSTox Substance ID:DTXSID50447865
Wikidata:Q82266758
Mol file:139718-50-6.mol

Synonyms:139718-50-6;5-Bromo-1-(4-fluorophenyl)-3-(piperidin-4-yl)-1H-indole;1H-Indole, 5-bromo-1-(4-fluorophenyl)-3-(4-piperidinyl)-;SCHEMBL6599893;DTXSID50447865

Suppliers and Price of 1H-Indole, 5-bromo-1-(4-fluorophenyl)-3-(4-piperidinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1H-Indole, 5-bromo-1-(4-fluorophenyl)-3-(4-piperidinyl)-

Chemical Property:

XLogP3:4.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:372.06374
Heavy Atom Count:23
Complexity:393

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CNCCC1C2=CN(C3=C2C=C(C=C3)Br)C4=CC=C(C=C4)F

Technology Process of 1H-Indole, 5-bromo-1-(4-fluorophenyl)-3-(4-piperidinyl)-

There total 6 articles about 1H-Indole, 5-bromo-1-(4-fluorophenyl)-3-(4-piperidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.3%

: 1273523-86-6
C₁₉H₁₆BrFN₂*ClH

: 139718-50-6
5-bromo-1-(4-fluorophenyl)-3-(4-piperidyl)-1H-indole

Guidance literature:: C₁₉H₁₆BrFN₂*ClH; With sodium hydroxide; In dichloromethane; water; for 0.5h; pH=11 - 12;

With platinum(IV) oxide; hydrogen; acetic acid; In methanol; at 30 - 35 ℃; for 4h; under 2795.17 - 3089.4 Torr; pH=6 - 7; Autoclave;
DOI:10.3762/bjoc.7.5

Reference yield:

: 489468-61-3
5-bromo-1-(4-fluorophenyl)-3-(1,2,3,6-tetrahydro-4-pyridyl)-1H-indole

: 139718-50-6
5-bromo-1-(4-fluorophenyl)-3-(4-piperidyl)-1H-indole

Guidance literature:: With hydrogen; platinum(IV) oxide; In acetic acid; for 48h; under 1471.02 - 2206.52 Torr;
DOI:10.1016/S0968-0896(02)00459-5

Reference yield:

: 138900-24-0
1-(4-fluorophenyl)-5-bromo-1H-indole

: 139718-50-6
5-bromo-1-(4-fluorophenyl)-3-(4-piperidyl)-1H-indole

Guidance literature:: Multi-step reaction with 2 steps

1: TFA / acetic acid / 1.5 h / Heating

2: H₂ / PtO₂ / acetic acid / 48 h / 1471.02 - 2206.52 Torr

With hydrogen; trifluoroacetic acid; platinum(IV) oxide; In acetic acid;
DOI:10.1016/S0968-0896(02)00459-5