(1S)-1-[3-[(2-Methoxyethoxy)methoxy]phenyl]-1,2-ethanediol

Base Information

Chemical Name:(1S)-1-[3-[(2-Methoxyethoxy)methoxy]phenyl]-1,2-ethanediol
CAS No.:215439-44-4
Molecular Formula:C₁₂H₁₈O₅
Molecular Weight:242.272
Hs Code.:
Mol file:215439-44-4.mol

Synonyms:

Suppliers and Price of (1S)-1-[3-[(2-Methoxyethoxy)methoxy]phenyl]-1,2-ethanediol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(1S)-1-[3-[(2-Methoxyethoxy)methoxy]phenyl]-1,2-ethanediol
25mg
$ 80.00

American Custom Chemicals Corporation
(1S)-1-(3-((2-METHOXYETHOXY)METHOXY)PHENYL)-1,2-ETHANEDIOL 95.00%
500MG
$ 1593.90

American Custom Chemicals Corporation
(1S)-1-(3-((2-METHOXYETHOXY)METHOXY)PHENYL)-1,2-ETHANEDIOL 95.00%
50MG
$ 269.85

Total 2 raw suppliers

Chemical Property of (1S)-1-[3-[(2-Methoxyethoxy)methoxy]phenyl]-1,2-ethanediol

Chemical Property:

Boiling Point:399.4±42.0 °C(Predicted)
PKA:13.48±0.20(Predicted)
Density:1.186±0.06 g/cm3(Predicted)
Solubility.:Dichloromethane, Methanol

Purity/Quality:

97% ^*data from raw suppliers

(1S)-1-[3-[(2-Methoxyethoxy)methoxy]phenyl]-1,2-ethanediol ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Byproduct formed during the production of Phenylephrine.

Technology Process of (1S)-1-[3-[(2-Methoxyethoxy)methoxy]phenyl]-1,2-ethanediol

There total 3 articles about (1S)-1-[3-[(2-Methoxyethoxy)methoxy]phenyl]-1,2-ethanediol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1-(3-methoxyethoxymethyloxy)phenylethylene oxide

: 215439-44-4
(1S)-1-{3-[(2-methoxyethoxy)methoxy]phenyl}ethane-1,2-diol

: (R)-1-(3-methoxyethoxymethyloxy)phenylethylene oxide

Guidance literature:: With (R,R)-Jacobsen catalyst; In water; at 0 - 20 ℃; for 61h; Resolution of racemate;
DOI:10.1021/op970128+

Reference yield:

: 139461-72-6
(3-methoxyethoxymethyloxy)benzaldehyde

: 215439-44-4
(1S)-1-{3-[(2-methoxyethoxy)methoxy]phenyl}ethane-1,2-diol

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 0 °C

1.2: 0.5 h / 20 °C

2.1: (R,R)-Jacobsen catalyst / water / 61 h / 0 - 20 °C / Resolution of racemate

With (R,R)-Jacobsen catalyst; sodium hydride; In water; dimethyl sulfoxide; mineral oil;
DOI:10.1021/op970128+

Reference yield:

: 100-83-4
meta-hydroxybenzaldehyde

: 215439-44-4
(1S)-1-{3-[(2-methoxyethoxy)methoxy]phenyl}ethane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C

2.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.25 h / 0 °C

2.2: 0.5 h / 20 °C

3.1: (R,R)-Jacobsen catalyst / water / 61 h / 0 - 20 °C / Resolution of racemate

With (R,R)-Jacobsen catalyst; sodium hydride; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; dimethyl sulfoxide; mineral oil;
DOI:10.1021/op970128+