2'-Piperidinoazohexestrol Dimethyl Ether

Base Information

• Chemical Name: 2'-Piperidinoazohexestrol Dimethyl Ether
• CAS No.: 77153-66-3
• Molecular Formula: C₂₅H₃₅N₃O₂
• Molecular Weight: 409.572
• Mol file: 77153-66-3.mol

Synonyms:

Chemical Property of 2'-Piperidinoazohexestrol Dimethyl Ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-Piperidinoazohexestrol Dimethyl Ether

There total 1 articles about 2'-Piperidinoazohexestrol Dimethyl Ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meso-3,4-Bis(4-methoxyphenyl)hexan (130-78-9) → 2'-Piperidinoazohexestrol Dimethyl Ether (77153-66-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) Br₂, 2.) KNH₂ / 1.) CCl₄, from 0 deg C to 5 deg C, 30 min, 2.) ammonia (liquid), THF, 1.5 h

2: 1.) concentrated HCl, NaNO₂ / 1.) 1:1 CH₃COCH₃-H₂O, 0 deg C, 30 min, 2.) 30 min

With hydrogenchloride; bromine; potassium amide; sodium nitrite;

DOI:10.1021/jo00325a017

Reference yield: 41.0%

2'-Piperidinoazohexestrol Dimethyl Ether (77153-66-3) → cis-3,6-Dimethoxy-9,10-diethyl-9,10-dihydrophenanthrene (77153-72-1) + 2'-Fluorohexestrol Dimethyl Ether (77153-70-9)

Guidance literature:

With hydrogen fluoride; 1.) room temperature, 30 min, 2.) 50 deg C, 10 min;

DOI:10.1021/jo00325a017

Reference yield:

2'-Piperidinoazohexestrol Dimethyl Ether (77153-66-3) → 2'-Fluorohexestrol (77153-71-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 41 percent / 48percent aqueous HF / 1.) room temperature, 30 min, 2.) 50 deg C, 10 min

2: 83 percent / BBr₃ / CHCl₃ / 0.33 h / Heating

With hydrogen fluoride; boron tribromide; In chloroform;

DOI:10.1021/jo00325a017

upstream raw materials:

meso-3,4-Bis(4-methoxyphenyl)hexan

Downstream raw materials:

cis-3,6-Dimethoxy-9,10-diethyl-9,10-dihydrophenanthrene

2'-Fluorohexestrol Dimethyl Ether

9,10-Diethyl-3,6-dimethoxy-phenanthren

2'-Fluorohexestrol