(R)-2-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-phenyl-buta-2,3-dien-1-ol

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Chemical Name:(R)-2-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-phenyl-buta-2,3-dien-1-ol
CAS No.:149180-78-9
Molecular Formula:C₂₂H₂₈O₇
Molecular Weight:404.46
Hs Code.:

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Chemical Property of (R)-2-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-phenyl-buta-2,3-dien-1-ol

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Technology Process of (R)-2-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-phenyl-buta-2,3-dien-1-ol

There total 1 articles about (R)-2-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-phenyl-buta-2,3-dien-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: C₁₅H₂₁LiO₆

: 149180-78-9
(R)-2-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-phenyl-buta-2,3-dien-1-ol

Guidance literature:: Multistep reaction;
DOI:10.1016/0040-4039(95)02125-6

Reference yield:

: 149180-78-9
(R)-2-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-phenyl-buta-2,3-dien-1-ol

: (1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(S)-oxiranyl-2-phenyl-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: p-dimethylaminopyridine / CH₂Cl₂ / 72 h

2: 50 percent CF₃CO₂H / CH₂Cl₂ / 3 h

3: 98 percent / NaBH₄, CeCl₃*7H₂O / methanol / 1 h / -78 °C

4: TBHP / VO(acac)2 / CH₂Cl₂ / 0 °C

With tert.-butylhydroperoxide; dmap; sodium tetrahydroborate; cerium(III) chloride; trifluoroacetic acid; bis(acetylacetonate)oxovanadium; In methanol; dichloromethane;
DOI:10.1016/0040-4039(95)02125-6

Reference yield:

: 149180-78-9
(R)-2-[(3aR,5R,6S,6aR)-5-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-yloxy]-1-phenyl-buta-2,3-dien-1-ol

: (1R,2R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-(R)-oxiranyl-2-phenyl-ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: p-dimethylaminopyridine / CH₂Cl₂ / 72 h

2: 50 percent CF₃CO₂H / CH₂Cl₂ / 3 h

3: 98 percent / NaBH₄, CeCl₃*7H₂O / methanol / 1 h / -78 °C

4: TBHP / VO(acac)2 / CH₂Cl₂ / 0 °C

With tert.-butylhydroperoxide; dmap; sodium tetrahydroborate; cerium(III) chloride; trifluoroacetic acid; bis(acetylacetonate)oxovanadium; In methanol; dichloromethane;
DOI:10.1016/0040-4039(95)02125-6