2H-1,6,7,8,9,9a-hexahydro-4-phenyl-1-oxa-5-azabenzazulene

Base Information

• Chemical Name: 2H-1,6,7,8,9,9a-hexahydro-4-phenyl-1-oxa-5-azabenzazulene
• CAS No.: 140655-34-1
• Molecular Formula: C₁₇H₁₇NO
• Molecular Weight: 251.328

Synonyms:

Chemical Property of 2H-1,6,7,8,9,9a-hexahydro-4-phenyl-1-oxa-5-azabenzazulene

Chemical Property:

Purity/Quality:

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Technology Process of 2H-1,6,7,8,9,9a-hexahydro-4-phenyl-1-oxa-5-azabenzazulene

There total 4 articles about 2H-1,6,7,8,9,9a-hexahydro-4-phenyl-1-oxa-5-azabenzazulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cycloheptane-1,3-dione (1194-18-9) → 2H-1,6,7,8,9,9a-hexahydro-4-phenyl-1-oxa-5-azabenzazulene (140655-34-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 78 percent

2: 99 percent / NaBH₄ / ethanol / 0.5 h / Ambient temperature

3: 1) NaH / 1) THF, r.t., 2) reflux, 24 h

4: 83 percent / nitrobenzene / 140 °C / t1/2

With sodium tetrahydroborate; sodium hydride; In ethanol; nitrobenzene;

DOI:10.1016/S0040-4020(01)88723-8

Reference yield:

5H-2-phenyl-6,7,8,9-tetrahydrocycloheptapyrimidin-5-one (140655-01-2) → 2H-1,6,7,8,9,9a-hexahydro-4-phenyl-1-oxa-5-azabenzazulene (140655-34-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 99 percent / NaBH₄ / ethanol / 0.5 h / Ambient temperature

2: 1) NaH / 1) THF, r.t., 2) reflux, 24 h

3: 83 percent / nitrobenzene / 140 °C / t1/2

With sodium tetrahydroborate; sodium hydride; In ethanol; nitrobenzene;

DOI:10.1016/S0040-4020(01)88723-8

Reference yield:

5H-5-hydroxy-2-phenyl-6,7,8,9-tetrahydrocycloheptapyrimidine (140655-09-0) → 2H-1,6,7,8,9,9a-hexahydro-4-phenyl-1-oxa-5-azabenzazulene (140655-34-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) THF, r.t., 2) reflux, 24 h

2: 83 percent / nitrobenzene / 140 °C / t1/2

With sodium hydride; In nitrobenzene;

DOI:10.1016/S0040-4020(01)88723-8

upstream raw materials:

cycloheptane-1,3-dione

5H-2-phenyl-6,7,8,9-tetrahydrocycloheptapyrimidin-5-one

5H-5-hydroxy-2-phenyl-6,7,8,9-tetrahydrocycloheptapyrimidine

benzamidin

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