[(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[2'-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-ylmethyl]-amine

Base Information

• Chemical Name: [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[2'-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-ylmethyl]-amine
• CAS No.: 94235-79-7
• Molecular Formula: C₃₇H₅₇NO₄Si₂
• Molecular Weight: 636.035
• Mol file: 94235-79-7.mol

Synonyms:

Chemical Property of [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[2'-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-ylmethyl]-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[2'-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-ylmethyl]-amine

There total 6 articles about [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[2'-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-ylmethyl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethoxybenzoic acid (1521-38-6) → [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[2'-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-ylmethyl]-amine (94235-79-7,94293-24-0)

Guidance literature:

Multi-step reaction with 6 steps

1: oxalyl chloride / CH₂Cl₂ / 14 h

2: 30 percent NH₄OH

3: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, 22 h; 2.) 1,2-dichloroethane, 24 h, reflux

4: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h

5: 1 M DIBAL / diethyl ether / Ambient temperature

6: tetrahydrofuran / 12 h / Ambient temperature

With ammonium hydroxide; oxalyl dichloride; triethyloxonium fluoroborate; diisobutylaluminium hydride; magnesium; In tetrahydrofuran; diethyl ether; dichloromethane;

DOI:10.1021/ja00289a023

Reference yield:

2,3-dimethoxybenzamide (1521-39-7) → [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[2'-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-ylmethyl]-amine (94235-79-7,94293-24-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) triethyloxonium tetrafluoroborate / 1.) 1,2-dichloroethane, 22 h; 2.) 1,2-dichloroethane, 24 h, reflux

2: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h

3: 1 M DIBAL / diethyl ether / Ambient temperature

4: tetrahydrofuran / 12 h / Ambient temperature

With triethyloxonium fluoroborate; diisobutylaluminium hydride; magnesium; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja00289a023

Reference yield:

(4S,5S)-2-(2,3-Dimethoxy-phenyl)-4-methoxymethyl-5-phenyl-4,5-dihydro-oxazole (94235-68-4) → [(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[2'-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-ylmethyl]-amine (94235-79-7,94293-24-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.) Mg / 1.) ether, 1 h; 2.) ether, THF, 24 h

2: 1 M DIBAL / diethyl ether / Ambient temperature

3: tetrahydrofuran / 12 h / Ambient temperature

With diisobutylaluminium hydride; magnesium; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ja00289a023

upstream raw materials:

tert-butyldimethylsilyl chloride

(1S,2S)-2-{[2'-(tert-Butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-ylmethyl]-amino}-3-methoxy-1-phenyl-propan-1-ol

2,3-dimethoxybenzoic acid

2,3-dimethoxybenzamide

Downstream raw materials:

[(1S,2S)-2-(tert-Butyl-dimethyl-silanyloxy)-1-methoxymethyl-2-phenyl-ethyl]-[1-[2'-(tert-butyl-dimethyl-silanyloxymethyl)-6-methoxy-biphenyl-2-yl]-meth-(E)-ylidene]-amine

C₃₇H₅₆ClNO₄Si₂