(1'R,2S,3R,4S,5S)-3-(dimethylphenyl)silane-4-methyl-2-(1'-methoxy)-5-phenyl-pyrrolidine-N-methyl carbamate-2-acetic acid methyl ester

Base Information

• Chemical Name: (1'R,2S,3R,4S,5S)-3-(dimethylphenyl)silane-4-methyl-2-(1'-methoxy)-5-phenyl-pyrrolidine-N-methyl carbamate-2-acetic acid methyl ester
• CAS No.: 155345-41-8
• Molecular Formula: C₂₅H₃₃NO₅Si
• Molecular Weight: 455.626
• Mol file: 155345-41-8.mol

Synonyms:

Chemical Property of (1'R,2S,3R,4S,5S)-3-(dimethylphenyl)silane-4-methyl-2-(1'-methoxy)-5-phenyl-pyrrolidine-N-methyl carbamate-2-acetic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1'R,2S,3R,4S,5S)-3-(dimethylphenyl)silane-4-methyl-2-(1'-methoxy)-5-phenyl-pyrrolidine-N-methyl carbamate-2-acetic acid methyl ester

There total 2 articles about (1'R,2S,3R,4S,5S)-3-(dimethylphenyl)silane-4-methyl-2-(1'-methoxy)-5-phenyl-pyrrolidine-N-methyl carbamate-2-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzaldehyde dimethyl acetal (1125-88-8) + (E)-(2S,3S)-methyl 3-(dimethylphenylsilyl)-2-methoxyhex-4-enoate (134333-46-3) + methyl carbamate (598-55-0) → (2S,3R,4S,5S)-3-(Dimethyl-phenyl-silanyl)-2-((S)-methoxy-methoxycarbonyl-methyl)-4-methyl-5-phenyl-pyrrolidine-1-carboxylic acid methyl ester + (1'R,2S,3R,4S,5S)-3-(dimethylphenyl)silane-4-methyl-2-(1'-methoxy)-5-phenyl-pyrrolidine-N-methyl carbamate-2-acetic acid methyl ester (155345-41-8)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at -100 - -78 ℃; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1021/jo00089a004

Reference yield:

benzaldehyde dimethyl acetal (1125-88-8) + (E)-(2S,3S)-methyl 3-(dimethylphenylsilyl)-2-methoxyhex-4-enoate (134333-46-3) + methyl carbamate (598-55-0) → (1'R,2S,3R,4S,5S)-3-(dimethylphenyl)silane-4-methyl-2-(1'-methoxy)-5-phenyl-pyrrolidine-N-methyl carbamate-2-acetic acid methyl ester (155345-41-8)

Guidance literature:

benzaldehyde dimethyl acetal; methyl carbamate; With boron trifluoride diethyl etherate; In dichloromethane; at -78 - 20 ℃;

(E)-(2S,3S)-methyl 3-(dimethylphenylsilyl)-2-methoxyhex-4-enoate; In dichloromethane; at -100 - -85 ℃;

DOI:10.1016/S0040-4020(00)00870-X

Reference yield:

(1'R,2S,3R,4S,5S)-3-(dimethylphenyl)silane-4-methyl-2-(1'-methoxy)-5-phenyl-pyrrolidine-N-methyl carbamate-2-acetic acid methyl ester (155345-41-8) → (2S,5R,6S,3E)-methyl-5-methyl-6-(N-methylcarbamate)-2-methoxy-6-phenyl-hexenoate

Guidance literature:

With boron trifluoride diethyl etherate; at -10 ℃;

DOI:10.1021/jo00089a004

upstream raw materials:

benzaldehyde dimethyl acetal

(E)-(2S,3S)-methyl 3-(dimethylphenylsilyl)-2-methoxyhex-4-enoate

methyl carbamate