Technology Process of ((3aS,5R,6S,7S,7aS)-6,7-Bis-benzyloxy-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethoxy)-tert-butyl-diphenyl-silane
There total 9 articles about ((3aS,5R,6S,7S,7aS)-6,7-Bis-benzyloxy-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-5-ylmethoxy)-tert-butyl-diphenyl-silane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(3aS,4R,5S,6S,7S,7aR)-6,7-Bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-4-ol;
With
carbon disulfide; sodium hydride; methyl iodide;
In
tetrahydrofuran;
at 0 - 20 ℃;
With
2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride;
In
toluene;
at 85 ℃;
for 0.5h;
DOI:10.1002/ejoc.200300339
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 72 percent / NaH; Bu4NI / tetrahydrofuran / 3 h
2.1: 85 percent / PPTS / methanol / 24 h
3.1: 90 percent / imidazole / dimethylformamide / 12 h / 20 °C
4.1: NaH; CS2; MeI / tetrahydrofuran / 0 - 20 °C
4.2: 201 mg / HSnBu3; AIBN / toluene / 0.5 h / 85 °C
With
1H-imidazole; carbon disulfide; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; methyl iodide;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.200300339
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: 57 percent / pyridine / CH2Cl2 / 2 h / 0 °C
2.1: 76 percent / pyridine / acetonitrile / 1 h / 85 °C
3.1: 23 percent / Bu3SnH; AIBN / toluene / 12 h / 85 °C
4.1: 70 percent / K2CO3 / methanol
5.1: O3 / methanol; CH2Cl2 / -78 °C
6.1: 205 mg / NaBH4; CeCl3*H2O / methanol / 0 - 20 °C
7.1: 72 percent / NaH; Bu4NI / tetrahydrofuran / 3 h
8.1: 85 percent / PPTS / methanol / 24 h
9.1: 90 percent / imidazole / dimethylformamide / 12 h / 20 °C
10.1: NaH; CS2; MeI / tetrahydrofuran / 0 - 20 °C
10.2: 201 mg / HSnBu3; AIBN / toluene / 0.5 h / 85 °C
With
pyridine; 1H-imidazole; carbon disulfide; sodium tetrahydroborate; cerium(III) chloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; pyridinium p-toluenesulfonate; tetra-(n-butyl)ammonium iodide; sodium hydride; potassium carbonate; ozone; methyl iodide;
In
tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1002/ejoc.200300339
![(3aS,4R,5S,6S,7S,7aR)-6,7-Bis-benzyloxy-5-(tert-butyl-diphenyl-silanyloxymethyl)-2,2-dimethyl-hexahydro-benzo[1,3]dioxol-4-ol](/Databaselist/images/loading.webp)
