(4S)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

Base Information

Chemical Name:(4S)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate
CAS No.:1616389-36-6
Molecular Formula:C₄₀H₄₉N₄O₇P
Molecular Weight:728.825
Hs Code.:

(4S)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

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Technology Process of (4S)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

There total 3 articles about (4S)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1651865-13-2
C₃₁H₃₂N₂O₆

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 1616389-36-6
(4S)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.666667h; Inert atmosphere;
DOI:10.1039/c4ob00149d

Reference yield:

: 5466-00-2
1,5,6,7-tetrahydro-cyclopentapyrimidine-2,4-dione

: 1616389-36-6
(4S)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 80 °C

1.2: 80 °C / Inert atmosphere

2.1: dmap; pyridine / 20 °C / Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 20 °C / Inert atmosphere

With pyridine; dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c4ob00149d

Reference yield:

: 611-10-9
2-ethoxycarbonyl-1-cyclopentanone

: 1616389-36-6
(4S)-1-(2,4-dioxo-3,4,6,7-tetrahydro-2H-cyclopenta[d]pyrimidin-1(5H)-yl)-3-((3-methoxyphenyl)(4-methoxyphenyl)(phenyl)methoxy)-propan-2-yl-P-2-cyanoethyl-N,N-cianopropylphosphonamidate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogenchloride / ethanol / 3 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 80 °C

2.2: 80 °C / Inert atmosphere

3.1: dmap; pyridine / 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.67 h / 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; dmap; potassium carbonate; N-ethyl-N,N-diisopropylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c4ob00149d