6-Boc-2,6-diazabicyclo[3.2.0]heptane

Base Information

• Chemical Name: 6-Boc-2,6-diazabicyclo[3.2.0]heptane
• CAS No.: 1408075-03-5
• Molecular Formula: C₁₀H₁₈N₂O₂
• Molecular Weight: 198.265
• Mol file: 1408075-03-5.mol

Synonyms:

Chemical Property of 6-Boc-2,6-diazabicyclo[3.2.0]heptane

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

6-Boc-2,6-diazabicyclo[3.2.0]heptane 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-Boc-2,6-diazabicyclo[3.2.0]heptane

There total 18 articles about 6-Boc-2,6-diazabicyclo[3.2.0]heptane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-Pyroglutaminol (17342-08-4) → C10H18N2O2 (1408075-03-5)

Guidance literature:

Multi-step reaction with 12 steps

1.1: toluene-4-sulfonic acid / toluene / 48 h / 125 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -65 °C

2.2: 1 h / -65 °C

2.3: 3 h / 0 - 25 °C

3.1: potassium carbonate; tert.-butylhydroperoxide / N,N-dimethyl-formamide / 0.5 h / 25 °C / Inert atmosphere

3.2: 1 h / 20 °C / Inert atmosphere

4.1: acetic acid; sodium tetrahydroborate; diphenyl diselenide / ethanol / 0.5 h / 25 °C

5.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 70 °C

6.1: palladium on activated charcoal; hydrogen / methanol / 16 h / 40 °C / 2585.81 Torr

7.1: triethylamine / dichloromethane / 4 h / 0 °C

8.1: toluene / 16 h / 110 °C

9.1: hydrogenchloride / acetonitrile; 1,4-dioxane / 0.5 h / 25 °C

10.1: triethylamine / dichloromethane; water / 1 h / 0 - 25 °C

11.1: palladium on activated charcoal; hydrogen / methanol / 16 h / 40 °C / 2585.81 Torr

12.1: caesium carbonate / water; methanol / 0.5 h / 40 °C

With hydrogenchloride; tert.-butylhydroperoxide; sodium tetrahydroborate; dimethylsulfide borane complex; diphenyl diselenide; palladium on activated charcoal; hydrogen; potassium carbonate; caesium carbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

tert-butyl (1R,5R)-2-(2,2,2-trifluoroacetyl)-2,6-diazabicyclo[3.2.0]heptane-6-carboxylate → C10H18N2O2 (1408075-03-5)

Guidance literature:

With caesium carbonate; In methanol; water; at 40 ℃; for 0.5h;

Reference yield:

tert-butyl (1S,5S)-2-(2,2,2-trifluoroacetyl)-2,6-diazabicyclo[3.2.0]heptane-6-carboxylate → tert-butyl (1S,5S)-2,6-diazabicyclo[3.2.0]heptane-6-carboxylate (1408075-03-5)

Guidance literature:

With caesium carbonate; In methanol; water; at 40 ℃; for 0.5h;

upstream raw materials:

(7aS)-3-phenyltetrahydro-3H,5H-pyrrolo[1,2-c]oxazol-5-one

(2R,3S)-N-benzyl-3-hydroxy-2-hydroxymethylpyrrolidine

(2R,3S)-tert-butyl 3-hydroxy-2-(hydroxymethyl)pyrrolidine-1-carboxylate

tert-butyl (2R,3S)-3-((methylsulfonyl)oxy)-2-(((methylsulfonyl)oxy)methyl)pyrrolidine-1-carboxylate