6-(4-methoxy-phenyl)-5-oxo-hexanenitrile

Base Information

Chemical Name:6-(4-methoxy-phenyl)-5-oxo-hexanenitrile
CAS No.:744256-32-4
Molecular Formula:C₁₃H₁₅NO₂
Molecular Weight:217.268
Hs Code.:

Synonyms:

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Chemical Property of 6-(4-methoxy-phenyl)-5-oxo-hexanenitrile

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Technology Process of 6-(4-methoxy-phenyl)-5-oxo-hexanenitrile

There total 1 articles about 6-(4-methoxy-phenyl)-5-oxo-hexanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135579-85-0
3-cyanopropylzinc bromide

: 4693-91-8
4-methoxyphenyl-acetic chloride

: 744256-32-4
6-(4-methoxy-phenyl)-5-oxo-hexanenitrile

Guidance literature:: With lithium bromide; In tetrahydrofuran;
DOI:10.1016/j.bmcl.2004.04.100

Reference yield:

: 744256-32-4
6-(4-methoxy-phenyl)-5-oxo-hexanenitrile

: (2S,3R)-2-(7-Bromo-heptyl)-6-triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiine

Guidance literature:: Multi-step reaction with 12 steps

1: pyridinium hydrochloride / 190 °C

2: Hunig's base / dimethylformamide

3: PTAB / CH₂Cl₂ / 0 °C

4: Et₃N / CH₂Cl₂

5: 59 percent / TFA; Et₃SiH / CH₂Cl₂

6: formic acid; Pd black / ethyl acetate

7: Hunig's base / dimethylformamide

8: DIBAL / toluene; CH₂Cl₂

9: BuLi / tetrahydrofuran

10: H₂ / Pd / ethanol; ethyl acetate

11: formic acid / Pd black / ethanol; ethyl acetate

12: CBr₄; PPh₃ / CH₂Cl₂

With triethylsilane; n-butyllithium; formic acid; carbon tetrabromide; PTAB; hydrogen; pyridine hydrochloride; diisobutylaluminium hydride; palladium; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; palladium; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 9: Wittig olefination;
DOI:10.1016/j.bmcl.2004.04.100

Reference yield:

: 744256-32-4
6-(4-methoxy-phenyl)-5-oxo-hexanenitrile

: 7-[(2S,3R)-6-Triisopropylsilanyloxy-3-(4-triisopropylsilanyloxy-phenyl)-2,3-dihydro-benzo[1,4]oxathiin-2-yl]-heptan-1-ol

Guidance literature:: Multi-step reaction with 11 steps

1: pyridinium hydrochloride / 190 °C

2: Hunig's base / dimethylformamide

3: PTAB / CH₂Cl₂ / 0 °C

4: Et₃N / CH₂Cl₂

5: 59 percent / TFA; Et₃SiH / CH₂Cl₂

6: formic acid; Pd black / ethyl acetate

7: Hunig's base / dimethylformamide

8: DIBAL / toluene; CH₂Cl₂

9: BuLi / tetrahydrofuran

10: H₂ / Pd / ethanol; ethyl acetate

11: formic acid / Pd black / ethanol; ethyl acetate

With triethylsilane; n-butyllithium; formic acid; PTAB; hydrogen; pyridine hydrochloride; diisobutylaluminium hydride; palladium; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; toluene; 9: Wittig olefination;
DOI:10.1016/j.bmcl.2004.04.100