[4,7-bis-butoxycarbonylmethyl-10-(2-(2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetamido)ethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester

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Chemical Name:[4,7-bis-butoxycarbonylmethyl-10-(2-(2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetamido)ethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester
CAS No.:1278587-15-7
Molecular Formula:C₅₈H₁₀₁N₇O₁₅
Molecular Weight:1136.48
Hs Code.:

[4,7-bis-butoxycarbonylmethyl-10-(2-(2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetamido)ethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester

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Chemical Property of [4,7-bis-butoxycarbonylmethyl-10-(2-(2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetamido)ethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester

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Technology Process of [4,7-bis-butoxycarbonylmethyl-10-(2-(2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetamido)ethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester

There total 13 articles about [4,7-bis-butoxycarbonylmethyl-10-(2-(2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetamido)ethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 824984-75-0
1-(2-aminoethyl)-1,4,7,10-tetraazacyclododecane-4,7,10-triacetic acid tri(1,1-dimethylethyl ester)

: 1278587-14-6
2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetic acid

: 1278587-15-7
[4,7-bis-butoxycarbonylmethyl-10-(2-(2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetamido)ethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1002/chem.201001548

Reference yield:

: 1278587-10-2
benzyl 2-(2-(2-(benzylamino)ethoxy)phenoxy)ethylcarbamate

: 1278587-15-7
[4,7-bis-butoxycarbonylmethyl-10-(2-(2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetamido)ethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C / 2585.81 Torr / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

4: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 0 - 20 °C / Inert atmosphere

5: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1002/chem.201001548

Reference yield:

: 1278587-09-9
benzyl 2-(2-(2-aminoethoxy)phenoxy)ethylcarbamate

: 1278587-15-7
[4,7-bis-butoxycarbonylmethyl-10-(2-(2-((2-(2-(2-(bis(2-tert-butoxy-2-oxoethyl)amino)ethoxy)phenoxy)ethyl)(2-tert-butoxy-2-oxoethyl)amino)acetamido)ethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: benzene / 20 °C / Molecular sieve; Inert atmosphere

2: sodium tetrahydroborate / methanol / Inert atmosphere

3: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

4: palladium 10% on activated carbon; hydrogen / methanol / 18 h / 20 °C / 2585.81 Torr / Inert atmosphere

5: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C / Inert atmosphere

6: water; lithium hydroxide / tetrahydrofuran; methanol / 2 h / 0 - 20 °C / Inert atmosphere

7: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; sodium tetrahydroborate; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; benzene;
DOI:10.1002/chem.201001548